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Human receptors for sweet and umami taste
- Source :
- Proceedings of the National Academy of Sciences of the United States of America. 99(7)
- Publication Year :
- 2002
-
Abstract
- The three members of the T1R class of taste-specific G protein-coupled receptors have been hypothesized to function in combination as heterodimeric sweet taste receptors. Here we show that human T1R2/T1R3 recognizes diverse natural and synthetic sweeteners. In contrast, human T1R1/T1R3 responds to the umami taste stimulus l -glutamate, and this response is enhanced by 5′-ribonucleotides, a hallmark of umami taste. The ligand specificities of rat T1R2/T1R3 and T1R1/T1R3 correspond to those of their human counterparts. These findings implicate the T1Rs in umami taste and suggest that sweet and umami taste receptors share a common subunit.
- Subjects :
- Multidisciplinary
Molecular Sequence Data
Guanosine Monophosphate
GPR120
Glutamic Acid
Receptors, Cell Surface
Umami
Biology
Biological Sciences
Gustducin
Transfection
Rats
Receptors, G-Protein-Coupled
TAS1R1
TAS2R38
TAS1R3
Biochemistry
Taste receptor
GTP-Binding Proteins
Inosine Monophosphate
Taste
Animals
Humans
TRPM5
Amino Acid Sequence
Subjects
Details
- ISSN :
- 00278424
- Volume :
- 99
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Accession number :
- edsair.doi.dedup.....a8c3fc9a60cff074f3af69d9cc2f26ad