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Prevalence, correlates, and impact of coronary calcification on adverse events following PCI with newer-generation DES: Findings from a large multiethnic registry
- Source :
- Catheterization and cardiovascular interventions : official journal of the Society for Cardiac AngiographyInterventions. 91(5)
- Publication Year :
- 2017
-
Abstract
- Objectives We sought to determine the prevalence, predictors, and clinical impact of target lesion calcification in patients undergoing percutaneous coronary intervention (PCI) with newer generation drug-eluting stents (DES) and devices. Background Coronary calcification is independently associated with adverse outcomes following PCI. While newer DES and contemporary devices are considered safer and more efficacious, their influence on outcomes following PCI of heavily calcified lesions is unknown. Methods We performed a retrospective analysis of a large, multiethnic cohort of patients undergoing PCI with new generation DES at an academic center between 2009 and 2013. Coronary calcification was qualitatively assessed as none/mild, moderate, or severe. Independent demographic, clinical, and anatomic predictors of moderate/severe calcification were identified using logistic regression. Associations between coronary calcification and 1-year MACE (death, myocardial infarction, or target vessel revascularization) were examined using Cox modeling. Results Compared to patients with none/mild (n = 10,180; 82.0%), those with moderate (n = 1,271; 10.0%) or severe (n = 994; 8.0%) calcification were older, more often Caucasian, had more complex target lesions, and worse renal function. The strongest demographic, clinical, and anatomic correlates of moderate/severe calcification were age, Caucasian race, renal dysfunction, lesion length, and left main location. Unadjusted MACE rates among those with none/mild, moderate, and severe calcification were 8.3, 14.6, and 17.8%, respectively (P
- Subjects :
- Target lesion
Male
medicine.medical_specialty
Time Factors
medicine.medical_treatment
Health Status
Coronary Artery Disease
030204 cardiovascular system & hematology
Prosthesis Design
Risk Assessment
Severity of Illness Index
White People
03 medical and health sciences
0302 clinical medicine
Percutaneous Coronary Intervention
Risk Factors
Internal medicine
medicine
Prevalence
Humans
Radiology, Nuclear Medicine and imaging
030212 general & internal medicine
Myocardial infarction
Registries
Adverse effect
Vascular Calcification
Aged
Retrospective Studies
Aged, 80 and over
Academic Medical Centers
business.industry
Hazard ratio
Age Factors
Percutaneous coronary intervention
Drug-Eluting Stents
General Medicine
Middle Aged
medicine.disease
Treatment Outcome
Conventional PCI
Cardiology
Female
New York City
Radiology
Cardiology and Cardiovascular Medicine
business
Mace
Calcification
Subjects
Details
- ISSN :
- 1522726X
- Volume :
- 91
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Catheterization and cardiovascular interventions : official journal of the Society for Cardiac AngiographyInterventions
- Accession number :
- edsair.doi.dedup.....a8cfc588ad20b5bc796bc8b2e00d407b