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High frequency variations of Helicobacter pylori isolates in individual hosts in a Chinese population
- Source :
- International Journal of Infectious Diseases. 16(5):e358-e363
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- SummaryBackgroundColonization of individual hosts by multiple Helicobacter pylori genotypes may be one reason why this infection is persistent and difficult to eradicate.MethodsIn order to study the diversity of H. pylori in individuals, a modified randomly amplified polymorphic DNA (RAPD) method was applied using primary culture isolates instead of passaged cultures.ResultsThe results showed that variations in H. pylori were prevalent among individuals in the Chinese population, and the incidence of multiple colonization was 99.1% (115/116), significantly higher than in other reports. Moreover, the number of RAPD genotypes was found to be significantly associated with the process of disease development (p
- Subjects :
- Adult
Male
Microbiology (medical)
Genotype
Molecular Sequence Data
Biology
Helicobacter Infections
Microbiology
Asian People
Bacterial Proteins
Humans
Colonization
Amino Acid Sequence
Stomach Ulcer
Allele
Aged
Aged, 80 and over
Genetics
Diversity
Helicobacter pylori
Strain (biology)
Incidence (epidemiology)
Individuals
Genetic Variation
General Medicine
Middle Aged
bacterial infections and mycoses
biology.organism_classification
Bacterial Typing Techniques
Random Amplified Polymorphic DNA Technique
Housekeeping gene
RAPD
Infectious Diseases
Duodenal Ulcer
Gastritis
Female
Multilocus Sequence Typing
Subjects
Details
- ISSN :
- 12019712
- Volume :
- 16
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- International Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....a8d34e0c6a72efd4d353b6a32a41cc4c
- Full Text :
- https://doi.org/10.1016/j.ijid.2012.01.006