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Novel 1,4-Substituted-1,2,3-Triazoles as Antitubercular Agents
- Source :
- ChemMedChem. 10:787-791
- Publication Year :
- 2015
- Publisher :
- Wiley, 2015.
-
Abstract
- Tuberculosis (TB) remains a pressing unmet medical need, particularly with the emergence of multidrug-resistant and extensively drug-resistant tuberculosis. Here, a series of 1,4-substituted-1,2,3-triazoles have been synthesized and evaluated as potential antitubercular agents. These compounds were assembled via click chemistry in high crude purity and in moderate to high yield. Of the compounds tested, 12 compounds showed promising antitubercular activity with six possessing minimum inhibitory concentration (MIC) values
- Subjects :
- Tuberculosis
Stereochemistry
Antitubercular Agents
Microbial Sensitivity Tests
Biochemistry
Mycobacterium tuberculosis
Structure-Activity Relationship
chemistry.chemical_compound
Minimum inhibitory concentration
Drug Discovery
medicine
General Pharmacology, Toxicology and Pharmaceutics
Pharmacology
Dose-Response Relationship, Drug
Molecular Structure
biology
Organic Chemistry
Triazoles
biology.organism_classification
medicine.disease
Combinatorial chemistry
chemistry
Mic values
Click chemistry
Molecular Medicine
Growth inhibition
Selectivity
Subjects
Details
- ISSN :
- 18607179
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- ChemMedChem
- Accession number :
- edsair.doi.dedup.....a8da6f1af6a172ff159875438c0a823b
- Full Text :
- https://doi.org/10.1002/cmdc.201500051