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A genetic variation of the p38β promoter region is correlated with an increased risk of sporadic colorectal cancer
- Source :
- Oncology Letters
- Publication Year :
- 2012
-
Abstract
- p38 plays a critical role in the proliferation, survival, migration and metastasis of colorectal cancer (CRC) cells. The present study assessed the correlation between a single nucleotide polymorphism (SNP) in the p38β promoter region (rs2235356, -1628A>G) and the predisposition of individuals to sporadic CRC in a case-control study. A genotyping method was developed to detect this SNP, using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. A logistic regression analysis was used to determine the odds ratio (OR) and 95% confidence interval (CI). It was revealed that the -1628G variant allele was correlated with an increased risk of CRC (OR, 1.99; 95% CI, 1.60-2.47; P
Details
- ISSN :
- 17921074
- Volume :
- 6
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Oncology letters
- Accession number :
- edsair.doi.dedup.....a8e1259da3acea5ecd34ea18fa8d004f