Additional file 1: Figure S1. of Pathological tau deposition in Motor Neurone Disease and frontotemporal lobar degeneration associated with TDP-43 proteinopathy

Îą-synuclein (a-c) pathology in cingulate gyrus (a), CA2 region of hippocampus (b) and substantia nigra (c) and TDP-43 pathology in anterior horn cells of the spinal cord (d-f), with fine, particulate accumulations of TDP-43 (d,e) or skein-like structures (e,f) being present in affected cells in which the nucleus has been â clearedâ of its normal immunoreactivity. Immunoperoxidase, x400 microscope magnification. (DOCX 6504Â kb)