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Time to Detection of Hepatitis C Virus Infection With the Xpert HCV Viral Load Fingerstick Point-of-Care Assay: Facilitating a More Rapid Time to Diagnosis
- Source :
- The Journal of Infectious Diseases. 221:2043-2049
- Publication Year :
- 2020
- Publisher :
- Oxford University Press (OUP), 2020.
-
Abstract
- Background Xpert HCV Viral Load Fingerstick assay (Xpert HCV VL FS) is a point-of-care test quantifying HCV RNA in Methods This study evaluated time to HCV RNA detection using the Xpert HCV VL FS assay. Fingerstick whole-blood samples were collected from participants in an observational cohort in Australia. Results In May 2018–2019, 1468 participants were enrolled, 1426 had Xpert HCV VL FS testing performed, and 1386 had a valid result. HCV RNA was detected in 23% (325/1386). Among people with undetectable HCV RNA (n = 1061), median time to result was 57 minutes. Among people with detectable HCV RNA (n = 325), median time to HCV RNA detection was 32 minutes and 80% (261/325) had a detectable HCV RNA result in ≤40 minutes. Median time to HCV RNA detection was dependent on HCV RNA level. Conclusions A quicker HCV diagnosis could be achieved by monitoring the time when HCV RNA is first detected with the Xpert HCV VL FS test, rather than HCV RNA quantification, although the current platform does not allow for this. These findings could facilitate new strategies to reduce waiting times for an HCV diagnosis and improve linkage to treatment.
- Subjects :
- Adult
Male
Waiting time
Time Factors
Fingerstick
Hepatitis C virus
Hepacivirus
medicine.disease_cause
Fingers
medicine
Humans
Immunology and Allergy
Point of care
Blood Specimen Collection
Time to detection
business.industry
virus diseases
Middle Aged
Viral Load
Hepatitis C
Virology
digestive system diseases
Infectious Diseases
Point-of-Care Testing
Cohort
Feasibility Studies
RNA, Viral
Female
Reagent Kits, Diagnostic
business
Viral load
Time to diagnosis
Subjects
Details
- ISSN :
- 15376613 and 00221899
- Volume :
- 221
- Database :
- OpenAIRE
- Journal :
- The Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....a948be04afca6d9d59f945367c21d16c