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Chlorogenic Acid Improves PTSD-like Symptoms and Associated Mechanisms
- Source :
- Current Neuropharmacology. 19:2180-2187
- Publication Year :
- 2021
- Publisher :
- Bentham Science Publishers Ltd., 2021.
-
Abstract
- Chlorogenic acid (CGA) is a kind of traditional Chinese medicine, abundant in honeysuckle and eucommia, and has a wide range of biological activities, and pharmacological effects. Previous studies have shown that CGA can regulate learning, memory, cognitive ability, coupled with improvement to anxiety, depression, and other post-traumatic stress disorder (PTSD)-like symptoms. This article explores the protective effects of CGA on neurons through its anti-apoptotic effect, inhibition of neuroinflammation and oxidative stress, which may be the mechanisms of its improvement of PTSD-like symptoms. It may provide a new therapeutic strategy for the treatment of PTSD and its comorbidities.
- Subjects :
- 0301 basic medicine
endocrine system
Traditional Chinese medicine
Anxiety
medicine.disease_cause
Bioinformatics
Stress Disorders, Post-Traumatic
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Chlorogenic acid
medicine
Humans
Pharmacology (medical)
Neuroinflammation
Therapeutic strategy
Pharmacology
business.industry
Cognition
General Medicine
Anxiety Disorders
Psychiatry and Mental health
030104 developmental biology
Neurology
chemistry
Neuroinflammatory Diseases
Neurology (clinical)
Chlorogenic Acid
medicine.symptom
business
030217 neurology & neurosurgery
Oxidative stress
Subjects
Details
- ISSN :
- 1570159X
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Current Neuropharmacology
- Accession number :
- edsair.doi.dedup.....a949be73fceed22b84a10dac497ee7c9