'Infarctoid Cardiopathy' Elicited by Temporary Obstruction of the Pylorus in Humorally Conditioned Animals

In rats pretreated with 2α-methyl-9α-chlorocortisol (Me-Cl-COL) and NaH2PO4, temporary occlusion of the pylorus regularly elicits acute, massive myocardial necroses and nephrocalcinosis, as well as a high mortality. The possible clinical implications of this fact, as regards the pathogenetic role of acute gastrointestinal disorders in the production of cardiac infarcts, is discussed.