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Common studied polymorphisms do not affect plasma cytokine levels upon endotoxin exposure in humans
- Source :
- Clinical and Experimental Immunology. 152:147-152
- Publication Year :
- 2008
- Publisher :
- Oxford University Press (OUP), 2008.
-
Abstract
- SummaryThe aim of this study was to investigate to what extent single nucleotide polymorphisms (SNPs) in promoter regions of genes of Toll-like receptor (TLR)-4, tumour necrosis factor (TNF)-α, interleukin (IL)-18, interferon (IFN)-γ, IL-6 and IL-10 affect the cytokine response during a controlled low-grade inflammatory response in vivo. Two hundred healthy young male volunteers were genotyped, and cytokine levels were measured in response to a low-dose intravenous bolus of Escherichia coli endotoxin. No association was detected between SNPs (TLR-4299, TLR-4399, TNF-308, IL-18-137, IL-18-607, IFN-γ+874, IL-6-174, IL-10-592 and IL-10-1082) and endotoxin-induced changes in plasma levels of TNF-α, IL-6 and IL-10. IL-18 levels were unaffected by endotoxin. In conclusion, the investigated SNPs did not affect endotoxin-induced low-grade cytokine production of TNF-α, IL-6, IL-18 or IL-10 in healthy young men. Previous reports of a major heritability factor in the inflammatory response may be due to other target genes or effects in older age groups or women.
- Subjects :
- Adult
Male
medicine.medical_specialty
Translational Studies
medicine.medical_treatment
Immunology
Inflammation
Single-nucleotide polymorphism
Biology
Polymorphism, Single Nucleotide
Interferon-gamma
Interferon
Internal medicine
medicine
Humans
Immunology and Allergy
Interferon gamma
Promoter Regions, Genetic
Receptor
Tumor Necrosis Factor-alpha
Interleukins
Interleukin
Endotoxemia
Endotoxins
Toll-Like Receptor 4
Cytokine
Endocrinology
Cytokines
Tumor necrosis factor alpha
medicine.symptom
medicine.drug
Subjects
Details
- ISSN :
- 13652249 and 00099104
- Volume :
- 152
- Database :
- OpenAIRE
- Journal :
- Clinical and Experimental Immunology
- Accession number :
- edsair.doi.dedup.....a95242829759bc337fbf649410793274
- Full Text :
- https://doi.org/10.1111/j.1365-2249.2008.03612.x