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Xingnaojing ameliorates synaptic plasticity and memory deficits in an Aβ1–42 induced mouse model of Alzheimer's disease
- Source :
- Journal of Pharmacological Sciences, Vol 143, Iss 4, Pp 245-254 (2020)
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- The accumulation of insoluble amyloid β (Aβ) peptides is one of the pathological changes in Alzheimer's disease (AD), which induced synaptic plasticity impairment and excitatory amino acid toxicity associated with decreased memory function. Xingnaojing (XNJ), a well-known prescription in traditional Chinese medicine, has been used for the treatment of stroke for many years in China. In this study, we aim to investigate the therapeutic effects of XNJ in a hippocampus of Aβ1–42 induced mouse model of AD which showed significant memory loss and impaired synaptic morphology and function. Treatment of XNJ could attenuate spatial and working memory dysfunction, increase dendritic spine density and improve long-term potential (LTP) induction. In addition, XNJ treatment significantly increased the level of N-methyl-d-aspartate receptors (NMDARs) and inhibit the NMDA/α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) ratio in AD mice. XNJ treatment also activated the AKT/mechanistic target of rapamycin (mTOR) pathway, while inhibition of the mTOR pathway by rapamycin could reverse the protective effects of XNJ treatment. In conclusion, XNJ protected against synaptic plasticity and memory impairment in AD mice via the activation of AKT/mTOR signaling pathway, suggesting XNJ as an alternative treatment for AD.
- Subjects :
- 0301 basic medicine
Dendritic spine
Hippocampus
AMPA receptor
Pharmacology
Synaptic plasticity
03 medical and health sciences
0302 clinical medicine
Xingnaojing
Medicine
Amyloid-β
Mechanistic target of rapamycin
PI3K/AKT/mTOR pathway
biology
business.industry
lcsh:RM1-950
Long-term potentiation
Alzheimer's disease
NMDAR
lcsh:Therapeutics. Pharmacology
030104 developmental biology
biology.protein
Molecular Medicine
NMDA receptor
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 13478613
- Volume :
- 143
- Database :
- OpenAIRE
- Journal :
- Journal of Pharmacological Sciences
- Accession number :
- edsair.doi.dedup.....a9571b5e711bf05d7c70283b0aea2d71