Interaction between substance P and gastrin-releasing peptide on thyrotropin secretion by rat pituitary in vitro

Authors :: Rachel Santos
Carlos Virgilio Morais Santos
C. C. Pazos-Moura
Egberto Gaspar de Moura
Source :: Brazilian Journal of Medical and Biological Research, Vol 32, Iss 9, Pp 1155-1160 (1999), Brazilian Journal of Medical and Biological Research v.32 n.9 1999, Brazilian Journal of Medical and Biological Research, Associação Brasileira de Divulgação Científica (ABDC), instacron:ABDC, Brazilian Journal of Medical and Biological Research, Volume: 32, Issue: 9, Pages: 1155-1160, Published: SEP 1999
Publication Year :: 1999
Publisher :: FapUNIFESP (SciELO), 1999.
Abstract: The effect of substance P (SP) on thyrotropin (TSH) secretion is controversial. In this study we evaluated the effect of SP on TSH secretion by hemipituitaries of 3-month-old Wistar rats in vitro and its interaction with gastrin-releasing peptide (GRP) at equimolar concentrations (1 microM and 10 microM). TSH release was measured under basal conditions and 30 min after incubation in the absence or presence of SP, GRP or both peptides. Pituitary TSH content was also measured in the pituitary homogenate after incubation. SP at both concentrations caused a significant (P

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