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Central-to-peripheral corneal edema during wear of embedded-component contact lenses
- Source :
- Contact lens & anterior eye : the journal of the British Contact Lens Association, vol 45, iss 1
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Purpose With active investigation underway for embedded-circuit contact lenses, safe oxygen supply of these novel lenses remains a question. Central-to-peripheral corneal edema for healthy eyes during wear of soft contact (SCL) and scleral lenses (SL) with embedding components is assessed. Methods Various 2-dimensional (2D) designs of SL and SCL with embedded components are constructed on Comsol Multiphysics 5.5. Local corneal swelling associated with the designed lenses is determined by a recently developed 2D metabolic-swelling model. Settled central post-lens tear-film thicknesses (PoLTFs) are set at 400 μm and 3 μm for SL and SCL designs, respectively. Each lens design has an axisymmetric central and an axisymmetric peripheral embedment. Oxygen permeability (Dk) of the lens and the embedments ranges from 0 to 200 Barrer. Dimensions and location of the embedments are varied to assess optimal-design configurations to minimize central-to-peripheral corneal edema. Results By adjusting oxygen Dk of the central embedment, the peripheral embedment, or the lens matrix polymer, corneal swelling is reduced by up to 2.5 %, 1.5 %, or 1.4 % of the baseline corneal thickness, respectively, while keeping all other parameters constant. A decrease in PoLTF thickness from 400 μm to 3 μm decreases corneal edema by up to 1.8 % of the baseline corneal thickness. Shifting the peripheral embedment farther out towards the periphery and towards the anterior lens surface reduces peak edema by up to 1.3 % and 0.6 % of the baseline corneal thickness, respectively. Conclusions To minimize central-to-peripheral corneal edema, embedments should be placed anteriorly and far into the periphery to allow maximal limbal metabolic support and oxygen transport in the polar direction (i.e., the θ-direction in spherical coordinates). High-oxygen transmissibility for all components and thinner PoLTF thickness are recommended to minimize corneal edema. Depending on design specifications, less than 1 % swelling over the entire cornea is achievable even with oxygen-impermeable embedments.
- Subjects :
- Hydrophilic
Materials science
genetic structures
Contact Lenses
Corneal metabolism
Limbal metabolic support
Scleral lens
Ophthalmology & Optometry
law.invention
Cornea
Contact-lens embedment
03 medical and health sciences
Oxygen permeability
0302 clinical medicine
Opthalmology and Optometry
law
Soft contact lens
Edema
medicine
Humans
Hypoxia
Eye Disease and Disorders of Vision
Embedment
Corneal Edema
Oxygen transport
Contact lens
General Medicine
Finite-element modeling
Contact Lenses, Hydrophilic
eye diseases
Oxygen
Lens (optics)
Ophthalmology
030221 ophthalmology & optometry
sense organs
Smart contact lens
Swelling
medicine.symptom
Sclera
030217 neurology & neurosurgery
Optometry
Biomedical engineering
Subjects
Details
- ISSN :
- 13670484
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Contact Lens and Anterior Eye
- Accession number :
- edsair.doi.dedup.....a96e149c079811146ef534cbade63fe9