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Race does not predict skeletal‐related events and all‐cause mortality in men with castration‐resistant prostate cancer
- Source :
- Cancer. 126:3274-3280
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- BACKGROUND The impact of race on prostate cancer skeletal-related events (SREs) remains understudied. In the current study, the authors tested the impact of race on time to SREs and overall survival in men with newly diagnosed, bone metastatic castration-resistant prostate cancer (mCRPC). METHODS The authors performed a retrospective study of patients from 8 Veterans Affairs hospitals who were newly diagnosed with bone mCRPC in the year 2000 or later. SREs comprised pathologic fracture, spinal cord compression, radiotherapy to the bone, or surgery to the bone. Time from diagnosis of bone mCRPC to SREs and overall mortality was estimated using the Kaplan-Meier method. Cox models tested the association between race and SREs and overall mortality. RESULTS Of 837 patients with bone mCRPC, 232 patients (28%) were black and 605 (72%) were nonblack. At the time of diagnosis of bone mCRPC, black men were found to be more likely to have more bone metastases compared with nonblack men (29% vs 19% with ≥10 bone metastases; P = .021) and to have higher prostate-specific antigen (41.7 ng/mL vs 29.2 ng/mL; P = .005) and a longer time from the diagnosis of CRPC to metastasis (17.9 months vs 14.3 months; P
- Subjects :
- Male
Risk
Oncology
Cancer Research
medicine.medical_specialty
Pathologic fracture
Bone Neoplasms
Kaplan-Meier Estimate
Metastasis
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Internal medicine
Humans
Medicine
030212 general & internal medicine
Veterans Affairs
Aged
Proportional Hazards Models
Retrospective Studies
Aged, 80 and over
Proportional hazards model
business.industry
Racial Groups
Hazard ratio
Absolute risk reduction
Retrospective cohort study
Prostate-Specific Antigen
Prognosis
medicine.disease
Prostatic Neoplasms, Castration-Resistant
Fractures, Spontaneous
030220 oncology & carcinogenesis
business
Spinal Cord Compression
Follow-Up Studies
Subjects
Details
- ISSN :
- 10970142 and 0008543X
- Volume :
- 126
- Database :
- OpenAIRE
- Journal :
- Cancer
- Accession number :
- edsair.doi.dedup.....a96e32b38353aadc989e7a1864fa2b41