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Pregnancy loss and risk of later dementia: A nationwide cohort study, Denmark, 1977–2017
- Source :
- Alzheimer's & Dementia : Translational Research & Clinical Interventions
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- Introduction Pregnancy losses may be associated with increased risks of dementia. Methods We conducted a register-based cohort study in 1,243,957 women with ≥1 pregnancy in Denmark in the period 1977–2015. Using Cox regression, we estimated hazard ratios (HRs) comparing risks of dementia in women with and without pregnancy losses. Results During 21,672,433 person-years of follow-up, 261,279 women experienced a pregnancy loss, and 2188 women were diagnosed with dementia. Stillbirth was associated with an 86% increased risk of dementia overall (HR 1.86, 95% confidence interval [CI] 1.28–2.71). By contrast, miscarriage was not associated with later risk of dementia overall (single miscarriage, HR 0.99, 95% CI 0.87–1.12; recurrent miscarriages, HR 1.06, 95% CI 0.84–1.35). Adjustment for cardiovascular disease, hypertension, and diabetes did not meaningfully alter the association magnitudes. Discussion Stillbirth and dementia may share underlying mechanisms, suggesting that a history of stillbirth should be considered when assessing dementia risk in women.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Miscarriage
Vascular dementia
03 medical and health sciences
0302 clinical medicine
Pregnancy loss
medicine
Dementia
Pregnancy
Proportional hazards model
Obstetrics
business.industry
Hazard ratio
Featured Article
Alzheimer's disease
Stillbirth
medicine.disease
Confidence interval
Psychiatry and Mental health
030104 developmental biology
Neurology (clinical)
business
030217 neurology & neurosurgery
Cohort study
Subjects
Details
- ISSN :
- 23528737
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Alzheimer's & Dementia: Translational Research & Clinical Interventions
- Accession number :
- edsair.doi.dedup.....a979396f9b8a0425e4be6413a6a133ab