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The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable
- Source :
- Knopman, D S, Haeberlein, S B, Carrillo, M C, Hendrix, J A, Kerchner, G, Margolin, R, Maruff, P, Miller, D S, Tong, G, Tome, M B, Murray, M E, Nelson, P T, Sano, M, Mattsson, N, Sultzer, D L, Montine, T J, Jack, C R, Kolb, H, Petersen, R C, Vemuri, P, Canniere, M Z, Schneider, J A, Resnick, S M, Romano, G, van Harten, A C, Wolk, D A, Bain, L J & Siemers, E 2018, ' The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable ', Alzheimer's and Dementia, vol. 14, no. 4, pp. 563-575 . https://doi.org/10.1016/j.jalz.2018.03.002, Alzheimer's and Dementia, 14(4), 563-575. Elsevier
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- The Alzheimer's Association's Research Roundtable met in November 2017 to explore the new National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease. The meeting allowed experts in the field from academia, industry, and government to provide perspectives on the new National Institute on Aging and the Alzheimer's Association Research Framework. This review will summarize the “A, T, N System” (Amyloid, Tau, and Neurodegeneration) using biomarkers and how this may be applied to clinical research and drug development. In addition, challenges and barriers to the potential adoption of this new framework will be discussed. Finally, future directions for research will be proposed.
- Subjects :
- 0301 basic medicine
Gerontology
Epidemiology
Neurofilament light
Disease
Article
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Drug Development
Developmental Neuroscience
Alzheimer Disease
National Institute on Aging (U.S.)
medicine
Humans
Clinical Trials as Topic
Government
Health Policy
medicine.disease
United States
Clinical neurology
Clinical trial
Psychiatry and Mental health
030104 developmental biology
Drug development
Conceptual framework
Neurology (clinical)
Geriatrics and Gerontology
Alzheimer's disease
Psychology
Biomarkers
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15525279 and 15525260
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Alzheimer's & Dementia
- Accession number :
- edsair.doi.dedup.....a98cb075f4fdeaccd076b4a16c739811
- Full Text :
- https://doi.org/10.1016/j.jalz.2018.03.002