Back to Search
Start Over
Evaluation of buprenorphine maintenance treatment in a French cohort of HIV-infected injecting drug users
- Source :
- Drug and Alcohol Dependence. 72:13-21
- Publication Year :
- 2003
- Publisher :
- Elsevier BV, 2003.
-
Abstract
- Background: Buprenorphine was approved in France for treating opiate dependence in July 1995 and can be prescribed by general practitioners (GPs). Most studies assessing buprenorphine maintenance treatment (BMT) outcomes have taken place in GP settings. An evaluation of BMT outcomes in patients already followed for their HIV-infection could supply additional information about the changes in addictive practices in a non-GP setting. Methods: We assessed BMT discontinuations and the course of self-reported addictive behaviours and characteristics associated with buprenorphine-injection misuse in 114 HIV-infected patients on BMT who were followed in a hospital-based outpatient department. Results: The continuous series of follow-up visits at which these 114 patients reported regular buprenorphine prescriptions accounted for 237.5 person-years of observation, i.e. 475 follow-up visits. Of the 114 patients on BMT, 43% continued BMT throughout the follow-up, 40% stopped it, and results for 17% were not available either because they did not answer the self-administered questionnaire (5%) or because they were lost to follow-up (12%). Addictive behaviours declined but buprenorphine injection misuse remained stable. Depression measured by the CESD score (RR=1.04 95%CI [1.01–1.06]), cocaine use (RR=2.48 95%CI [1.31–4.68]) and alcohol consumption exceeding 4 alcohol units (AU) per day (RR=2.29, 95%CI [1.17–4.46]) were independently associated with buprenorphine injection misuse among stabilised BMT patients. Conclusions: Despite the reduction in drug injection after starting BMT, buprenorphine injection misuse mainly involves patients with characteristics of severe addiction. Better monitoring of the illicit drug use patterns of patients on BMT may suggest new medical strategies for GPs to improve BMT outcomes.
- Subjects :
- Adult
Male
medicine.medical_specialty
Narcotic Antagonists
media_common.quotation_subject
Toxicology
Severity of Illness Index
Unit of alcohol
Cohort Studies
Treatment Refusal
Cocaine-Related Disorders
Surveys and Questionnaires
HIV Seropositivity
medicine
Humans
Outpatient clinic
Pharmacology (medical)
Medical prescription
Substance Abuse, Intravenous
media_common
Pharmacology
Drug injection
Depression
Heroin Dependence
business.industry
Addiction
Buprenorphine
Surgery
Psychiatry and Mental health
Injections, Intravenous
Cohort
Emergency medicine
Female
business
Follow-Up Studies
medicine.drug
Cohort study
Subjects
Details
- ISSN :
- 03768716
- Volume :
- 72
- Database :
- OpenAIRE
- Journal :
- Drug and Alcohol Dependence
- Accession number :
- edsair.doi.dedup.....a9954c6d826f8f2900e13247c50ea7f7