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Disturbed gut microbiota and bile homeostasis in Giardia-infected mice contributes to metabolic dysregulation and growth impairment
- Source :
- Science Translational Medicine, 12(565):7019. American Association for the Advancement of Science
- Publication Year :
- 2020
- Publisher :
- American Association for the Advancement of Science, 2020.
-
Abstract
- Although infection with the human enteropathogen Giardia lamblia causes self-limited diarrhea in adults, infant populations in endemic areas experience persistent pathogen carriage in the absence of diarrhea. The persistence of this protozoan parasite in infants has been associated with reduced weight gain and linear growth (height-for-age). The mechanisms that support persistent infection and determine the different disease outcomes in the infant host are incompletely understood. Using a neonatal mouse model of persistent G. lamblia infection, we demonstrate that G. lamblia induced bile secretion and used the bile constituent phosphatidylcholine as a substrate for parasite growth. In addition, we show that G. lamblia infection altered the enteric microbiota composition, leading to enhanced bile acid deconjugation and increased expression of fibroblast growth factor 15. This resulted in elevated energy expenditure and dysregulated lipid metabolism with reduced adipose tissue, body weight gain, and growth in the infected mice. Our results indicate that this enteropathogen's modulation of bile acid metabolism and lipid metabolism in the neonatal mouse host led to an altered body composition, suggesting how G. lamblia infection could contribute to growth restriction in infants in endemic areas.
- Subjects :
- 0301 basic medicine
LAMBLIA
medicine.drug_class
IMPACT
030106 microbiology
Adipose tissue
INFANTS
CHILDREN
Biology
Gut flora
Fibroblast growth factor
medicine.disease_cause
Microbiology
03 medical and health sciences
LIPID-METABOLISM
parasitic diseases
DIARRHEAL DISEASE
medicine
Giardia lamblia
DEVELOPING-COUNTRIES
Pathogen
Bile acid
Lipid metabolism
General Medicine
biology.organism_classification
DUODENALIS
Diarrhea
030104 developmental biology
ACID
medicine.symptom
RESPONSES
Subjects
Details
- Language :
- English
- ISSN :
- 19466234
- Volume :
- 12
- Issue :
- 565
- Database :
- OpenAIRE
- Journal :
- Science Translational Medicine
- Accession number :
- edsair.doi.dedup.....a99ec731265635a577ae4c3126645853