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Antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae
- Source :
- Photodiagnosis and Photodynamic Therapy
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Despite great efforts, the design of antibacterial surfaces is still a challenge. In this work, results of structural, mechanical, cytotoxic and antibacterial activities of hydrophobic carbon quantum dots/polydimethylsiloxane surfaces are presented. Antibacterial action of this surface is based on the generation of reactive oxygen species which cause bacteria damage by oxidative stress. At the same time, this surface was not cytotoxic towards the NIH/3T3 cells. Swelling-encapsulation-shrink method is applied for encapsulation of hydrophobic carbon quantum dots in medical grade silicone-polydimethylsiloxane. XPS and photoluminescence spectroscopy analyses confirm that hydrophobic carbon quantum dots have been encapsulated successfully into polydimethylsiloxane polymer matrix. Based on stress-strain test the improvement of mechanical properties of these nanocomposites is established. It is shown by electron paramagnetic resonance spectroscopy and luminescence method that nanocomposite generates singlet oxygen initiated by 470 nm blue light irradiation. Antibacterial testing shows the nanocomposite in the form of foil kills Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae and is very effective after only a 15 min irradiation. © 2019 Elsevier B.V. This is peer-reviewed version of the article: Marković, Zoran M., Mária Kováčová, Petr Humpolíček, Milica D. Budimir, Jan Vajďák, Pavel Kubát, Matej Mičušík et al. "Antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae." Photodiagnosis and photodynamic therapy 26 (2019): 342-349. [http://dx.doi.org/10.1016/j.pdpdt.2019.04.019] Published version: [https://vinar.vin.bg.ac.rs/handle/123456789/8174]
- Subjects :
- Staphylococcus aureus
Photoluminescence
Surface Properties
Biophysics
02 engineering and technology
Dermatology
Hydrophobic carbon quantum dots
010402 general chemistry
medicine.disease_cause
Photochemistry
01 natural sciences
Nanocomposites
Mice
chemistry.chemical_compound
X-ray photoelectron spectroscopy
Quantum Dots
Escherichia coli
medicine
Animals
Pharmacology (medical)
Dimethylpolysiloxanes
Visible light sterilization
chemistry.chemical_classification
Nanocomposite
Medical grade polydimethylsiloxane
Antimicrobial photodynamic therapy
Singlet Oxygen
Polydimethylsiloxane
Singlet oxygen
Polymer
021001 nanoscience & nanotechnology
Carbon
0104 chemical sciences
Klebsiella pneumoniae
Photochemotherapy
Oncology
chemistry
Antibacterial surfaces
0210 nano-technology
Luminescence
Subjects
Details
- ISSN :
- 15721000
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Photodiagnosis and Photodynamic Therapy
- Accession number :
- edsair.doi.dedup.....a9b410b1513094e97f7c250b47dccbd0