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Diminished liver microperfusion in Fontan patients
- Source :
- PLoS ONE, 12(3). PUBLIC LIBRARY SCIENCE, PLoS ONE, Vol 12, Iss 3, p e0173149 (2017), PLoS ONE
- Publication Year :
- 2017
- Publisher :
- PUBLIC LIBRARY SCIENCE, 2017.
-
Abstract
- It has been demonstrated that hepatic apparent diffusion coefficients (ADC) are decreasing in patients with a Fontan circulation. It remains however unclear whether this is a true decrease of molecular diffusion, or rather reflects decreased microperfusion due to decreased portal blood flow. The purpose of this study was therefore to differentiate diffusion and microperfusion using intravoxel incoherent motion (IVIM) modeled diffusion-weighted imaging (DWI) for different liver segments in patients with a Fontan circulation, compare to a control group, and relate with liver function, chronic hepatic congestion and hepatic disease. For that purpose, livers of 59 consecutively included patients with Fontan circulation (29 men; mean-age, 19.1 years) were examined (Oct 2012-Dec 2013) with 1.5T MRI and DWI (b = 0,50,100,250,500, 750,1500,1750 s/mm(2)). IVIM (D-slow,D-fast,f(fast)) and ADC were calculated for eight liver segments, compared to a control group (19 volunteers; 10 men; mean-age, 32.9 years), and correlated to follow-up duration, clinical variables, and laboratory measurements associated with liver function. The results demonstrated that microperfusion was reduced (p
- Subjects :
- Liver Cirrhosis
Male
Cirrhosis
Cardiovascular Procedures
lcsh:Medicine
030204 cardiovascular system & hematology
Fontan Procedure
Diagnostic Radiology
030218 nuclear medicine & medical imaging
0302 clinical medicine
HEPATOCELLULAR-CARCINOMA
Medicine and Health Sciences
Medicine
Child
lcsh:Science
Intravoxel incoherent motion
Brain Mapping
Multidisciplinary
medicine.diagnostic_test
Liver Diseases
Radiology and Imaging
Fatty liver
Magnetic Resonance Imaging
Perfusion
CONGENITAL HEART-DISEASE
Liver
Cardiology
Liver Fibrosis
Female
Radiology
CHRONIC HEPATITIS-C
Research Article
Adult
medicine.medical_specialty
Adolescent
Imaging Techniques
Brain Morphometry
CARDIAC CIRRHOSIS
Surgical and Invasive Medical Procedures
Neuroimaging
Gastroenterology and Hepatology
Research and Analysis Methods
INITIAL-EXPERIENCE
INTRAVOXEL INCOHERENT MOTION
03 medical and health sciences
Diagnostic Medicine
Internal medicine
Humans
Fontan Operation
Diffusion Weighted Imaging
business.industry
lcsh:R
Biology and Life Sciences
Magnetic resonance imaging
Blood flow
Models, Theoretical
medicine.disease
Fibrosis
Fatty Liver
Diffusion Magnetic Resonance Imaging
CHRONIC PASSIVE CONGESTION
TRICUSPID-ATRESIA
DIFFUSION-WEIGHTED MRI
PERFUSION MEASUREMENT
lcsh:Q
Liver function
business
Magnetic Resonance Angiography
Developmental Biology
Neuroscience
Diffusion MRI
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 12
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- PLOS-One
- Accession number :
- edsair.doi.dedup.....a9b75e0a3ab1dbb5cff22788545a0294