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Neuroendocrine disruption without direct endocrine mode of action: Polychloro-biphenyls (PCBs) and bisphenol A (BPA) as case studies
- Source :
- Comptes Rendus Biologies. 340:432-438
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Endocrine disruption is commonly thought to be restricted to a direct endocrine mode of action i.e. the perturbation of the activation of a given type of hormonal receptor by its natural ligand. Consistent with the WHO definition of an endocrine disrupter, a key issue is the “altered function(s) of the endocrine system”. Such altered functions can result from different chemical interactions, beyond agonistic or antagonistic effect at a given receptor. Based on neuroendocrine disruption by polychlorinated biphenyls and bisphenol A, this paper proposes different mechanistic paradigms that can result in adverse health effects. They are a consequence of altered endocrine function(s) secondary to chemical interaction with different steps in the physiological regulatory processes, thus accounting for a possibly indirect endocrine mode of action.
- Subjects :
- 0301 basic medicine
Bisphenol A
medicine.medical_specialty
Chemical interaction
Endocrine Disruptors
Biology
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Phenols
Adverse health effect
Internal medicine
medicine
Animals
Humans
Endocrine system
Benzhydryl Compounds
Mode of action
Receptor
Perturbateurs endocriniens
General Immunology and Microbiology
General Medicine
Polychlorinated Biphenyls
030104 developmental biology
Endocrinology
chemistry
General Agricultural and Biological Sciences
Neuroscience
030217 neurology & neurosurgery
Hormone
Subjects
Details
- ISSN :
- 16310691
- Volume :
- 340
- Database :
- OpenAIRE
- Journal :
- Comptes Rendus Biologies
- Accession number :
- edsair.doi.dedup.....a9bf77bf5a2b7012c904edffb26da0f1