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Choroidal Changes in Eyes With Polypoidal Choroidal Vasculopathy After Anti-VEGF Therapy Imaged With Swept-Source OCT Angiography
- Source :
- Investigative Ophthalmology & Visual Science
- Publication Year :
- 2021
- Publisher :
- Association for Research in Vision and Ophthalmology (ARVO), 2021.
-
Abstract
- Purpose Swept-source optical coherence tomography angiography was used to investigate choroidal changes and their association with pigment epithelial detachments (PEDs) in eyes with polypoidal choroidal vasculopathy (PCV) after treatment with vascular endothelial growth factor (VEGF) inhibitors. Methods Patients with treatment-naïve PCV were included and underwent anti-VEGF therapy. Mean choroidal thickness (MCT), choroidal vascularity index (CVI), and PED volume measurements were obtained before and after treatment. Results Thirty-four treatment-naïve PCV eyes from 33 patients were included. The PED volume decreased after treatment (P < 0.05). The MCT decreased from 223.0 ± 79.6 µm at baseline to 210.9 ± 76.2 µm after treatment (P < 0.001). The CVI at baseline was 0.599 ± 0.024, and the CVI after treatment was 0.602 ± 0.023 (P = 0.16). There was a correlation between the decreased PED volumes and the decreased MCT measurements (r = 0.47; P = 0.006). Also, there was a correlation between the decreased PED volumes and the increased CVI measurements (r = −0.63; P < 0.001). Conclusions In treatment-naïve eyes with PCV, the decreases in PED volumes were correlated with the decrease in MCT and the increase in CVI measurements. We propose that, at baseline, the PCV lesions serve as high-volume arteriovenous shunts between choroidal arterial and venous circulation, causing transudation into the choroidal stroma. We propose that, after treatment, the blood flow through the vascular shunt is reduced, the excess stromal transudation is resorbed, and the exudation from the neovascular lesion is reduced, resulting in thinning of the choroid, resolution of the PEDs, and an increase in the CVI due to the resorption of excess choroidal transudation.
- Subjects :
- Indocyanine Green
Male
Vascular Endothelial Growth Factor A
medicine.medical_specialty
Visual Acuity
Angiogenesis Inhibitors
polypoidal choroidal vasculopathy
Lesion
chemistry.chemical_compound
Polyps
Oct angiography
Vascularity
Ophthalmology
Humans
Medicine
Fluorescein Angiography
Coloring Agents
Aged
Retrospective Studies
Aged, 80 and over
Anti vegf
Choroid
business.industry
Clinical and Epidemiologic Research
OCT angiography
Blood flow
Middle Aged
Choroidal Neovascularization
eye diseases
Resorption
Vascular endothelial growth factor
medicine.anatomical_structure
chemistry
anti-VEGF
Intravitreal Injections
Female
sense organs
medicine.symptom
business
Tomography, Optical Coherence
Follow-Up Studies
Subjects
Details
- ISSN :
- 15525783
- Volume :
- 62
- Database :
- OpenAIRE
- Journal :
- Investigative Opthalmology & Visual Science
- Accession number :
- edsair.doi.dedup.....a9c087c83e579e4e94444dda500e962a