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Adherence, compliance and persistence to oral antineoplastic therapy: a review focused on chemotherapeutic and biologic agents
- Source :
- Expert Opinion on Drug Safety. 11:S49-S59
- Publication Year :
- 2011
- Publisher :
- Informa Healthcare, 2011.
-
Abstract
- Introduction: To date, orally administered chemotherapy and biologic agents represent a significant percentage of all antineoplastic treatments in several types of cancer, which are most likely to increase in the near future. In this scenario, the issue of adherence and persistence to oral therapy is a key issue since poor compliance to oral antineoplastic treatments may negatively influence patients' clinical outcomes and, in turn, cause an increase in costs, number of hospitalizations and time spent in the hospital. Areas covered: The issue of adherence to new oral chemotherapeutic and/or biologic agents has not been deeply evaluated and data published in medical literature are quite scarce. Adherence is a multidimensional phenomenon, which may be influenced by patient-and health-care provider-related factors, anticancer therapy itself, education and socioeconomic aspects. Patients' selection plays, therefore, a key role in maximizing adherence and persistence to oral therapies. Treating health-care practitioners should first evaluate patient reliability to avoid prescribing oral treatments to patients with socioeconomic and medical conditions, which may predict poor adherence. Expert opinion: Adherence and persistence to new oral biologic agents, which are linked to several side effects and whose use is constantly widening, should represent a main endpoint of clinical research in the nearest future. © 2012 Informa UK, Ltd.
- Subjects :
- medicine.medical_specialty
Settore MED/06 - Oncologia Medica
Poor compliance
medicine.medical_treatment
Administration, Oral
Antineoplastic Agents
Pharmacology
Socioeconomic Factor
Medication Adherence
Persistence (computer science)
Persistence
Antineoplastic Agent
Immunologic Factor
Neoplasms
Humans
Immunologic Factors
Medicine
Pharmacology (medical)
Intensive care medicine
Oral therapy
Cancer
Chemotherapy
business.industry
Health Care Costs
General Medicine
Drug adherence
medicine.disease
Biologic Agents
Health Care Cost
Hospitalization
Socioeconomic Factors
Adherence
Neoplasm
business
Oral chemotherapy
Human
Medical literature
Subjects
Details
- ISSN :
- 1744764X and 14740338
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Expert Opinion on Drug Safety
- Accession number :
- edsair.doi.dedup.....a9cd8a6c9645f1ac17b9fde212a2efd0
- Full Text :
- https://doi.org/10.1517/14740338.2011.645803