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Turning Observed Founder Alleles into Expected Relationships in an Intercross Population
- Source :
- G3: Genes|Genomes|Genetics, G3: Genes, Genomes, Genetics, Vol 9, Iss 3, Pp 889-899 (2019)
- Publication Year :
- 2019
- Publisher :
- Oxford University Press (OUP), 2019.
-
Abstract
- Pedigree-derived relationships for individuals from an intercross of several lines cannot easily account for the segregation variance that is mainly caused by loci with alternative alleles fixed in different lines. However, when all founders are genotyped for a large number of markers, such relationships can be derived for descendants as expected genomic relationships conditional on the observed founder allele frequencies. A tabular method was derived in detail for autosomes and the X-chromosome. As a case study, we analyzed litter size and body weights at three different ages in an advanced mouse intercross (29 generations, total pedigree size 19,266) between a line selected for high litter size (FL1) and a highly inbred control line (DUKsi). Approximately 60% of the total genetic variance was due to segregation variance. Estimated heritability values were 0.20 (0.03), 0.34 (0.04), 0.23 (0.03), 0.41 (0.03) and 0.47 (0.02) for litter size, litter weight and body weight at ages of 21, 42 and 63 days, respectively (standard errors in brackets). These values were between 12% and 65% higher than observed in analyses that treated founders as unrelated. Fields of applications include experimental populations (selection experiments or advanced intercross lines) with a limited number of founders, which can be genotyped at a reasonable cost. In principle any number of founder lines can be treated. Additional genotypes from individuals in later generations can be combined into a joint relationship matrix by capitalizing on previously published approaches.
- Subjects :
- Litter (animal)
sex-linked inheritance
Population
QH426-470
Investigations
Biology
03 medical and health sciences
Control line
Genetic variation
Genetics
founder genomic relationships
Allele
education
Molecular Biology
Allele frequency
Genetics (clinical)
030304 developmental biology
0303 health sciences
education.field_of_study
0402 animal and dairy science
X-chromosomal genomic relationships
04 agricultural and veterinary sciences
Heritability
040201 dairy & animal science
selection experiments
Evolutionary biology
litter size
growth traits
Sex linkage
Subjects
Details
- ISSN :
- 21601836
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- G3 Genes|Genomes|Genetics
- Accession number :
- edsair.doi.dedup.....a9ff7d292027aeffb65abe3395ac3ea8