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Voluntary exercise inhibits intestinal tumorigenesis in ApcMin/+ mice and azoxymethane/dextran sulfate sodium-treated mice
- Source :
- BMC Cancer, BMC Cancer, Vol 8, Iss 1, p 316 (2008)
- Publication Year :
- 2008
- Publisher :
- BioMed Central, 2008.
-
Abstract
- Background Epidemiological studies suggest that physical activity reduces the risk of colon cancer in humans. Results from animal studies, however, are inconclusive. The present study investigated the effects of voluntary exercise on intestinal tumor formation in two different animal models, Apc Min/+ mice and azoxymethane (AOM)/dextran sulfate sodium (DSS)-treated mice. Methods In Experiments 1 and 2, five-week old female Apc Min/+ mice were either housed in regular cages or cages equipped with a running wheel for 6 weeks (for mice maintained on the AIN93G diet; Experiment 1) or 9 weeks (for mice on a high-fat diet; Experiment 2). In Experiment 3, male CF-1 mice at 6 weeks of age were given a dose of AOM (10 mg/kg body weight, i.p.) and, 12 days later, 1.5% DSS in drinking fluid for 1 week. The mice were then maintained on a high-fat diet and housed in regular cages or cages equipped with a running wheel for 16 weeks. Results In the Apc Min/+ mice maintained on either the AIN93G or the high-fat diet, voluntary exercise decreased the number of small intestinal tumors. In the AOM/DSS-treated mice maintained on a high-fat diet, voluntary exercise also decreased the number of colon tumors. In Apc Min/+ mice, voluntary exercise decreased the ratio of serum insulin like growth factor (IGF)-1 to IGF binding protein (BP)-3 levels. It also decreased prostaglandin E2 and nuclear β-catenin levels, but increased E-cadherin levels in the tumors. Conclusion These results indicate hat voluntary exercise inhibited intestinal tumorigenesis in Apc Min/+ mice and AOM/DSS-treated mice, and the inhibitory effect is associated with decreased IGF-1/IGFBP-3 ratio, aberrant β-catenin signaling, and arachidonic acid metabolism.
- Subjects :
- Male
Cancer Research
Colorectal cancer
medicine.medical_treatment
chemistry.chemical_compound
Mice
0302 clinical medicine
Intestine, Small
Prostaglandin E2
beta Catenin
2. Zero hunger
0303 health sciences
Dextran Sulfate
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Cadherins
Oncology
Codon, Nonsense
030220 oncology & carcinogenesis
Female
Animal studies
Stem cell
medicine.drug
Research Article
medicine.medical_specialty
Beta-catenin
Genes, APC
Azoxymethane
Biology
lcsh:RC254-282
Dinoprostone
03 medical and health sciences
Internal medicine
Physical Conditioning, Animal
Intestinal Neoplasms
medicine
Genetics
Biomarkers, Tumor
Animals
Carcinogen
030304 developmental biology
Growth factor
medicine.disease
Dietary Fats
Mice, Mutant Strains
Insulin-Like Growth Factor Binding Protein 1
Disease Models, Animal
Endocrinology
Insulin-Like Growth Factor Binding Protein 3
chemistry
biology.protein
Carcinogens
Subjects
Details
- Language :
- English
- ISSN :
- 14712407
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- BMC Cancer
- Accession number :
- edsair.doi.dedup.....aa09ce6de315161783f87e576fa83807