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Recent Updates on Molecular Genetic Engineering Approaches and Applications of Human Therapeutic Proteins
- Source :
- Current Protein & Peptide Science. 18:217-232
- Publication Year :
- 2017
- Publisher :
- Bentham Science Publishers Ltd., 2017.
-
Abstract
- Therapeutic proteins are engineered proteins produced in the laboratory for pharmaceutical use. With the advent of recombinant DNA technology, the proteins can be generated in specific host cells under defined conditions. In the process of production of genetically engineered animals, the gene of interest can be added at a single cell stage to produce a cloned animal from genetically engineered cells. Several recombinant cytokines, clotting factors etc have been licensed and are currently being utilized for the treatment of cancer, infectious diseases, hemophilia, anemia, multiple sclerosis, and hepatitis B/C. Therapeutic proteins that are useful for human are successfully produced in poultry as well as in livestock animals. However, the fastest growing class of therapeutic proteins are antibodies especially monoclonal antibodies (mAb), the most important class of therapeutic protein with the potential to generate significant revolution in terms of clinical success rate. Here, we review the most recent clinical advances in the field of emerging and existing therapeutic proteins.
- Subjects :
- 0301 basic medicine
medicine.drug_class
Recombinant Fusion Proteins
Cell
Computational biology
Antibodies, Monoclonal, Humanized
Protein Engineering
Monoclonal antibody
030226 pharmacology & pharmacy
Biochemistry
law.invention
03 medical and health sciences
0302 clinical medicine
law
Granulocyte Colony-Stimulating Factor
medicine
Deoxyribonuclease I
Humans
Insulin-Like Growth Factor I
Immunoglobulin Fragments
Molecular Biology
Gene
Clotting factor
Factor VIII
biology
Cancer
Cell Biology
General Medicine
Single-Domain Antibodies
Hepatitis B
medicine.disease
Recombinant Proteins
030104 developmental biology
medicine.anatomical_structure
Tissue Plasminogen Activator
Immunology
Recombinant DNA
biology.protein
Cytokines
Interferons
Antibody
Subjects
Details
- ISSN :
- 13892037
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Current Protein & Peptide Science
- Accession number :
- edsair.doi.dedup.....aa0e764573447e1d6efad774093ae05f