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IL-4Rα blockade reduces influenza-associated morbidity in a murine model of allergic asthma
- Source :
- Respiratory Research, Vol 22, Iss 1, Pp 1-11 (2021), Respiratory Research
- Publication Year :
- 2021
- Publisher :
- BioMed Central, 2021.
-
Abstract
- Background Asthma was identified as the most common comorbidity in hospitalized patients during the 2009 H1N1 influenza pandemic. We determined using a murine model of allergic asthma whether these mice experienced increased morbidity from pandemic H1N1 (pH1N1) viral infection and whether blockade of interleukin-4 receptor α (IL-4Rα), a critical mediator of Th2 signalling, improved their outcomes. Methods Male BALB/c mice were intranasally sensitized with house dust mite antigen (Der p 1) for 2 weeks; the mice were then inoculated intranasally with a single dose of pandemic H1N1 (pH1N1). The mice were administered intraperitoneally anti-IL-4Rα through either a prophylactic or a therapeutic treatment strategy. Results Infection with pH1N1 of mice sensitized to house dust mite (HDM) led to a 24% loss in weight by day 7 of infection (versus 14% in non-sensitized mice; p Conclusion Together, these data implicate allergic asthma as a significant risk factor for H1N1-related morbidity and reveal a potential therapeutic role for IL-4Rα signalling blockade in reducing the severity of influenza infection in those with allergic airway disease.
- Subjects :
- 0301 basic medicine
Male
Receptors, Cell Surface
Systemic inflammation
03 medical and health sciences
Mice
0302 clinical medicine
Influenza A Virus, H1N1 Subtype
Antigen
Influenza, Human
medicine
Hypersensitivity
Eosinophilia
Animals
Humans
Asthma
House dust mite
lcsh:RC705-779
Mice, Inbred BALB C
biology
business.industry
Research
Pyroglyphidae
Antibodies, Monoclonal
lcsh:Diseases of the respiratory system
medicine.disease
biology.organism_classification
Blockade
respiratory tract diseases
Disease Models, Animal
030104 developmental biology
030228 respiratory system
Immunology
Nasal administration
medicine.symptom
business
Viral load
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Respiratory Research, Vol 22, Iss 1, Pp 1-11 (2021), Respiratory Research
- Accession number :
- edsair.doi.dedup.....aa16aad5a28d5451114f6bccc604e6c0
- Full Text :
- https://doi.org/10.14288/1.0396029