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An organoruthenium complex overcomes ABCG2-mediated multidrug resistance via multiple mechanisms
- Source :
- Chemical communications (Cambridge, England). 55(26)
- Publication Year :
- 2019
-
Abstract
- Multidrug resistance mediated by the overexpression of ABC transporters is a major challenge in cancer chemotherapy. Here, we report the synthesis of an organoruthenium complex, RuF, that was designed to surmount multidrug resistance by combining ABCG2 inhibition and cancer cell cytotoxicity, yielding synergistic efficacy.
- Subjects :
- Abcg2
ATP-binding cassette transporter
Antineoplastic Agents
Drug resistance
010402 general chemistry
01 natural sciences
Catalysis
Ruthenium
Structure-Activity Relationship
Cell Line, Tumor
Materials Chemistry
Organometallic Compounds
Structure–activity relationship
ATP Binding Cassette Transporter, Subfamily G, Member 2
Humans
Cytotoxicity
Cell Proliferation
biology
Dose-Response Relationship, Drug
Molecular Structure
010405 organic chemistry
Chemistry
Cell Cycle
Metals and Alloys
General Chemistry
Drug Resistance, Multiple
0104 chemical sciences
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Neoplasm Proteins
Multiple drug resistance
Cell culture
Drug Resistance, Neoplasm
Cancer cell
Ceramics and Composites
Cancer research
biology.protein
Drug Screening Assays, Antitumor
Subjects
Details
- ISSN :
- 1364548X
- Volume :
- 55
- Issue :
- 26
- Database :
- OpenAIRE
- Journal :
- Chemical communications (Cambridge, England)
- Accession number :
- edsair.doi.dedup.....aa44775699f782baec12c48faeacba40