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Dehydrocurvularin is a potent antineoplastic agent irreversibly blocking ATP-citrate lyase: evidence from chemoproteomics
- Source :
- Chemical communications (Cambridge, England). 55(29)
- Publication Year :
- 2019
-
Abstract
- Natural-product macrolide 10,11-dehydrocurvularin (DCV) was revealed to be a potent irreversible inhibitor of ATP-citrate lyase (ACLY) via classical chemoproteomic profiling, which mechanistically illuminates the anti-cancer mode of action of DCV and its analogues.
- Subjects :
- Proteomics
ATP citrate lyase
Antineoplastic Agents
010402 general chemistry
01 natural sciences
Catalysis
Materials Chemistry
Humans
Chemoproteomics
Enzyme Inhibitors
Mode of action
Cell Proliferation
010405 organic chemistry
Chemistry
Metals and Alloys
Dehydrocurvularin
General Chemistry
Lyase
0104 chemical sciences
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Biochemistry
Ceramics and Composites
ATP Citrate (pro-S)-Lyase
Zearalenone
HeLa Cells
Subjects
Details
- ISSN :
- 1364548X
- Volume :
- 55
- Issue :
- 29
- Database :
- OpenAIRE
- Journal :
- Chemical communications (Cambridge, England)
- Accession number :
- edsair.doi.dedup.....aa4970ae2f55076030a8205a1a490eb2