Back to Search Start Over

STIM proteins: dynamic calcium signal transducers

STIM proteins: dynamic calcium signal transducers

Authors :
Jonathan Soboloff
Muniswamy Madesh
Brad S. Rothberg
Donald L. Gill
Source :
Nature Reviews Molecular Cell Biology. 13:549-565
Publication Year :
2012
Publisher :
Springer Science and Business Media LLC, 2012.

Abstract

Stromal interaction molecule (STIM) proteins function in cells as dynamic coordinators of cellular calcium (Ca(2+)) signals. Spanning the endoplasmic reticulum (ER) membrane, they sense tiny changes in the levels of Ca(2+) stored within the ER lumen. As ER Ca(2+) is released to generate primary Ca(2+) signals, STIM proteins undergo an intricate activation reaction and rapidly translocate into junctions formed between the ER and the plasma membrane. There, STIM proteins tether and activate the highly Ca(2+)-selective Orai channels to mediate finely controlled Ca(2+) signals and to homeostatically balance cellular Ca(2+). Details are emerging on the remarkable organization within these STIM-induced junctional microdomains and the identification of new regulators and alternative target proteins for STIM.

Details

ISSN :
14710080 and 14710072
Volume :
13
Database :
OpenAIRE
Journal :
Nature Reviews Molecular Cell Biology
Accession number :
edsair.doi.dedup.....aa4ed05f8817c08fe91bff2535351032
Full Text :
https://doi.org/10.1038/nrm3414