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STIM proteins: dynamic calcium signal transducers
STIM proteins: dynamic calcium signal transducers
- Source :
- Nature Reviews Molecular Cell Biology. 13:549-565
- Publication Year :
- 2012
- Publisher :
- Springer Science and Business Media LLC, 2012.
-
Abstract
- Stromal interaction molecule (STIM) proteins function in cells as dynamic coordinators of cellular calcium (Ca(2+)) signals. Spanning the endoplasmic reticulum (ER) membrane, they sense tiny changes in the levels of Ca(2+) stored within the ER lumen. As ER Ca(2+) is released to generate primary Ca(2+) signals, STIM proteins undergo an intricate activation reaction and rapidly translocate into junctions formed between the ER and the plasma membrane. There, STIM proteins tether and activate the highly Ca(2+)-selective Orai channels to mediate finely controlled Ca(2+) signals and to homeostatically balance cellular Ca(2+). Details are emerging on the remarkable organization within these STIM-induced junctional microdomains and the identification of new regulators and alternative target proteins for STIM.
- Subjects :
- Stromal cell
chemistry.chemical_element
Biology
Calcium
Endoplasmic Reticulum
Models, Biological
Article
Animals
Humans
Calcium Signaling
Stromal Interaction Molecule 1
Stromal Interaction Molecule 2
Molecular Biology
ORAI1
Endoplasmic reticulum
Cell Membrane
Membrane Proteins
Cell Biology
STIM2
Neoplasm Proteins
Cell calcium
Cell biology
Intercellular Junctions
Membrane
chemistry
Cell Adhesion Molecules
Subjects
Details
- ISSN :
- 14710080 and 14710072
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Nature Reviews Molecular Cell Biology
- Accession number :
- edsair.doi.dedup.....aa4ed05f8817c08fe91bff2535351032
- Full Text :
- https://doi.org/10.1038/nrm3414