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Directed evolution of hybrid enzymes: Evolving enantioselectivity of an achiral Rh-complex anchored to a protein

Authors :
Matthias Maywald
Jérôme J.-P. Peyralans
Andrea Maichele
Yu Fu
Manfred T. Reetz
Source :
Chemical communications (Cambridge, England). (41)
Publication Year :
2006

Abstract

The concept of utilizing the methods of directed evolution for tuning the enantioselectivity of synthetic achiral metal-ligand centers anchored to proteins has been implemented experimentally for the first time.

Details

ISSN :
13597345
Issue :
41
Database :
OpenAIRE
Journal :
Chemical communications (Cambridge, England)
Accession number :
edsair.doi.dedup.....aa4ff9036205dc9bcdecdeb45c8fff7b