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Mathematical modeling of the glucagon challenge test
- Source :
- Masroor, S, van Dongen, M G J, Alvarez-Jimenez, R, Burggraaf, K, Peletier, L A & Peletier, M A 2019, ' Mathematical modeling of the glucagon challenge test ', Journal of Pharmacokinetics and Pharmacodynamics, vol. 46, no. 6, pp. 553-564 . https://doi.org/10.1007/s10928-019-09655-2, Journal of Pharmacokinetics and Pharmacodynamics, 46(6), 553-564. Springer New York, Journal of Pharmacokinetics and Pharmacodynamics, 46(6), 553-564. Springer, Journal of Pharmacokinetics and Pharmacodynamics
- Publication Year :
- 2019
-
Abstract
- A model for the homeostasis of glucose through the regulating hormones glucagon and insulin is described. It contains a subsystem that models the internalization of the glucagon receptor. Internalization is a mechanism in cell signaling, through which G-protein coupled receptors are taken from the surface of the cell to the endosome. The model is used to interpret data from a glucagon challenge test in which subjects have been under treatment with a novel glucagon receptor anti-sense drug which is aimed at reducing the number of receptors in the liver. It is shown how the receptor internalization results in tolerance of the blood glucose concentration to glucagon-induced hyperglycemia. We quantify the reduction of the number of receptors using the model and the data before and after treatment. Electronic supplementary material The online version of this article (doi:10.1007/s10928-019-09655-2) contains supplementary material, which is available to authorized users.
- Subjects :
- Blood Glucose
medicine.medical_specialty
endocrine system
Endosome
medicine.medical_treatment
media_common.quotation_subject
education
030209 endocrinology & metabolism
Receptor internalization
030226 pharmacology & pharmacy
Glucagon
03 medical and health sciences
0302 clinical medicine
Internal medicine
Receptors, Glucagon
medicine
Humans
Insulin
Receptor
Internalization
media_common
Pharmacology
Original Paper
RECEPTOR
Chemistry
digestive, oral, and skin physiology
Glucose Tolerance Test
Models, Theoretical
TARGET
Glucose
Endocrinology
Hyperglycemia
Glucagon receptor
SYSTEM
Homeostasis
hormones, hormone substitutes, and hormone antagonists
Hormone
Subjects
Details
- Language :
- English
- ISSN :
- 1567567X
- Database :
- OpenAIRE
- Journal :
- Masroor, S, van Dongen, M G J, Alvarez-Jimenez, R, Burggraaf, K, Peletier, L A & Peletier, M A 2019, ' Mathematical modeling of the glucagon challenge test ', Journal of Pharmacokinetics and Pharmacodynamics, vol. 46, no. 6, pp. 553-564 . https://doi.org/10.1007/s10928-019-09655-2, Journal of Pharmacokinetics and Pharmacodynamics, 46(6), 553-564. Springer New York, Journal of Pharmacokinetics and Pharmacodynamics, 46(6), 553-564. Springer, Journal of Pharmacokinetics and Pharmacodynamics
- Accession number :
- edsair.doi.dedup.....aa7bb96e230918b3d0c2038f9437777c