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Identification of risk loci with shared effects on five major psychiatric disorders:a genome-wide analysis
- Source :
- Cross-Disorder Group of the Psychiatric Genomics Consortium 2013, ' Identification of risk loci with shared effects on five major psychiatric disorders : a genome-wide analysis ', Lancet, vol. 381, no. 9875, pp. 1371-9 . https://doi.org/10.1016/S0140-6736(12)62129-1, The Lancet (London), 381, 1371-9, Lancet, 381(9875), 1371-1379. Elsevier Limited, Smoller, J W, Ripke, S, Lee, P H, Neale, B, Nurnberger, J I, Santangelo, S, Sullivan, P F, Perlis, R H, Purcell, S M, Fanous, A, Neale, M C, Rietschel, M, Schulze, T G, Thapar, A, Anney, R, Buitelaar, J K, Farone, S V, Hoogendijk, W J G, Levinson, D F, Lesch, K P, Riley, B, Schachar, R, Sonuga-Barke, E J, Absher, D, Agartz, I, Akil, H, Amin, F, Andreassen, O A, Anjorin, A, Arking, D, Asherson, P, Azevedo, M H, Backlund, L, Badner, J A, Banaschewski, T, Barchas, J D, Barnes, M R, Bass, N, Bauer, M C R, Bellivier, F, Bergen, S E, Berrettini, W, Bettecken, T, Biederman, J, Binder, E B, Black, D W, Blackwood, D H, Bloss, C S, Boehnke, M, Boomsma, D I, Breen, G, Breuer, R, Buccola, N G, Bunner, W E, Burmeister, M, Buxbaum, J D, Byerley, W F, Sian, C, Cantor, R M, Chakravarti, A, Chambert, K, Chicon, S, Cloniger, C R, Collier, D A, Cook, E, Coon, H, Corvin, A, Coryell, W H, Craig, D W, Craig, I W, Curtis, D, Czamara, D, Daly, M, Datta, S, Day, R, de Geus, E J C, Degenhardt, F, Devlin, B, Srdjan, D, Doyle, A E, Duan, J, Dudbridge, F, Edenberg, H J, Elkin, A, Etain, B, Farmer, A E, Ferreira, M A R, Ferrier, I N, Flickinger, M, Foroud, T, Frank, J, Franke, B, Fraser, C, Freedman, R, Freimer, N B, Friedl, M, Frisén, L, Gejman, P V, Georgieva, L, Gershon, E S, Giegling, I, Gill, M, Gordon, S D, Gordon-Smith, K, Green, E K, Greenwood, T A, Gross, M, Grozeva, D, Guan, W, Gurling, H, Gustafsson, O, Hakonarson, H, Hamilton, S P, Hamshere, M L, Hansen, T F, Hartmann, A M, Hautzinger, M, Heath, A C, Henders, A K, Herms, S, Hickie, I B, Hipolito, M, Hoefels, S, Holmans, P A, Holsboer, F, Hottenga, J J, Hultman, C M, Ingason, A, Ising, M, Jamain, S, Jones, E G, Jones, L, Jones, I, Jung-Ying, T, Kahler, A, Kandaswamy, R, Keller, M C, Kelsoe, J, Kennedy, J L, Kenny, E, Kim, Y, Kirov, G K, Knowles, J A, Kohli, M A, Koller, D L, Konte, B, Korszun, A, Krasucki, R, Kuntsi, J, Phoenix, K, Landén, M, Langstrom, N, Lathrop, M, Lawrence, J, Lawson, W B, Leboyer, M, Lencz, T, Lewis, C M, Li, J, Lichtenstein, P, Lieberman, J A, Lin, D, Liu, C, Lohoff, F W, Loo, S K, Lucae, S, MacIntyre, D J, Madden, P A F, Magnusson, P, Mahon, P B, Maier, W, Malhotra, A K, Mattheisen, M, Matthews, K, Mattingsdal, M, McCarroll, S, McGhee, K A, McGough, J J, McGrath, P J, McGuffin, P, McInnis, M G, McIntosh, A, McKinney, R, McClean, A W, McMahon, F J, McQuillin, A, Medeiros, H, Medland, S E, Meier, S, Melle, I, Meng, F, Middeldorp, C M, Middleton, L, Vihra, M, Mitchell, P B, Montgomery, G W, Moran, J, Morken, G, Morris, D W, Moskvina, V, Mowry, B J, Muglia, P, Mühleisen, T W, Muir, W J, Müller-Myhsok, B, Myers, R M, Nelson, S F, Nievergelt, C M, Nikolovq, I, Nimgaonkar, V L, Nolen, W A, Nöthen, M M, Nwulia, E A, Nyholt, DR, O'Donovan, M C, O'Dushlaine, C, Oades, R D, Olincy, A, Olsen, L, Ophoff, R A, Osby, U, Óskarsson, H, Owen, M J, Palotie, A, Pato, M T, Pato, C N, Penninx, B W J H, Pergadia, M L, Petursson, H, Pickard, B S, Pimm, J, Piven, J, Porgeirsson, P, Posthuma, D, Potash, J B, Propping, J, Puri, V, Quested, D, Quinn, E M, Rasmussen, H B, Raychaudhuri, S, Rehnström, K, Reif, A, Rice, J, Rossin, L, Rothenberger, A, Rouleau, G, Ruderfer, D, Rujescu, D, Sanders, A R, Schalling, M, Schatzberg, A F, Scheftner, W A, Schellenberg, G D, Schofield, P R, Schork, N J, Schumacher, J, Schwarz, M M, Scolnick, E, Scott, L J, Shi, J, Shillling, P D, Shyn, S I, Sigurdsson, E, Silverman, J M, Sklar, P, Slager, S L, Smalley, S L, Smit, J H, Smith, E N, Sonuga-Barke, E, St Clair, D, State, M, Stefansson, K, Stefansson, H, Steffans, M, Steinberg, S, Steinhausen, H C, Strauss, J, Strohmaier, J, Stroup, T S, Sutcliffe, J, Szatmari, P, Szelinger, S, Thirumalai, S, Thompson, R C, Tozzi, F, Treutlein, J, Uhr, M, van den Oord, E J, Grootheest, G, Vieland, V, Vincent, J B, Visscher, P M, Watson, S J, Weissman, M M, Werge, T, Wienker, T F, Willemsen, G, Williamson, R, Witt, S H, Wray, N R, Wright, A, Xu, W, Young, A H, Zammit, S, Zandi, P P, Zhang, P, Zitman, F G, Zöllner, S & Kendler, K S 2013, ' Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis ', Lancet, vol. 381, no. 9875, pp. 1371-1379 . https://doi.org/10.1016/S0140-6736(12)62129-1, Lancet, 381(9875), 1371-1379. Elsevier Science, The Lancet (London), 381, 9875, pp. 1371-9
- Publication Year :
- 2013
-
Abstract
- Item does not contain fulltext BACKGROUND: Findings from family and twin studies suggest that genetic contributions to psychiatric disorders do not in all cases map to present diagnostic categories. We aimed to identify specific variants underlying genetic effects shared between the five disorders in the Psychiatric Genomics Consortium: autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia. METHODS: We analysed genome-wide single-nucleotide polymorphism (SNP) data for the five disorders in 33,332 cases and 27,888 controls of European ancestory. To characterise allelic effects on each disorder, we applied a multinomial logistic regression procedure with model selection to identify the best-fitting model of relations between genotype and phenotype. We examined cross-disorder effects of genome-wide significant loci previously identified for bipolar disorder and schizophrenia, and used polygenic risk-score analysis to examine such effects from a broader set of common variants. We undertook pathway analyses to establish the biological associations underlying genetic overlap for the five disorders. We used enrichment analysis of expression quantitative trait loci (eQTL) data to assess whether SNPs with cross-disorder association were enriched for regulatory SNPs in post-mortem brain-tissue samples. FINDINGS: SNPs at four loci surpassed the cutoff for genome-wide significance (p
- Subjects :
- Netherlands Twin Register (NTR)
Adult
medicine.medical_specialty
Bipolar Disorder
Calcium Channels, L-Type
Population
Medizin
Genome-wide association study
Biology
Polymorphism, Single Nucleotide
Article
Genomic disorders and inherited multi-system disorders DCN MP - Plasticity and memory [IGMD 3]
medicine
ddc:61
Attention deficit hyperactivity disorder
Humans
DCN PAC - Perception action and control NCEBP 9 - Mental health
ddc:610
Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters
Bipolar disorder
Age of Onset
Psychiatry
education
Child
Genetics
education.field_of_study
Depressive Disorder, Major
General Medicine
Genomic disorders and inherited multi-system disorders [DCN PAC - Perception action and control IGMD 3]
medicine.disease
Logistic Models
Autism spectrum disorder
Schizophrenia
Attention Deficit Disorder with Hyperactivity
Child Development Disorders, Pervasive
Genetic Loci
Expression quantitative trait loci
Major depressive disorder
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 01406736
- Database :
- OpenAIRE
- Journal :
- Cross-Disorder Group of the Psychiatric Genomics Consortium 2013, ' Identification of risk loci with shared effects on five major psychiatric disorders : a genome-wide analysis ', Lancet, vol. 381, no. 9875, pp. 1371-9 . https://doi.org/10.1016/S0140-6736(12)62129-1, The Lancet (London), 381, 1371-9, Lancet, 381(9875), 1371-1379. Elsevier Limited, Smoller, J W, Ripke, S, Lee, P H, Neale, B, Nurnberger, J I, Santangelo, S, Sullivan, P F, Perlis, R H, Purcell, S M, Fanous, A, Neale, M C, Rietschel, M, Schulze, T G, Thapar, A, Anney, R, Buitelaar, J K, Farone, S V, Hoogendijk, W J G, Levinson, D F, Lesch, K P, Riley, B, Schachar, R, Sonuga-Barke, E J, Absher, D, Agartz, I, Akil, H, Amin, F, Andreassen, O A, Anjorin, A, Arking, D, Asherson, P, Azevedo, M H, Backlund, L, Badner, J A, Banaschewski, T, Barchas, J D, Barnes, M R, Bass, N, Bauer, M C R, Bellivier, F, Bergen, S E, Berrettini, W, Bettecken, T, Biederman, J, Binder, E B, Black, D W, Blackwood, D H, Bloss, C S, Boehnke, M, Boomsma, D I, Breen, G, Breuer, R, Buccola, N G, Bunner, W E, Burmeister, M, Buxbaum, J D, Byerley, W F, Sian, C, Cantor, R M, Chakravarti, A, Chambert, K, Chicon, S, Cloniger, C R, Collier, D A, Cook, E, Coon, H, Corvin, A, Coryell, W H, Craig, D W, Craig, I W, Curtis, D, Czamara, D, Daly, M, Datta, S, Day, R, de Geus, E J C, Degenhardt, F, Devlin, B, Srdjan, D, Doyle, A E, Duan, J, Dudbridge, F, Edenberg, H J, Elkin, A, Etain, B, Farmer, A E, Ferreira, M A R, Ferrier, I N, Flickinger, M, Foroud, T, Frank, J, Franke, B, Fraser, C, Freedman, R, Freimer, N B, Friedl, M, Frisén, L, Gejman, P V, Georgieva, L, Gershon, E S, Giegling, I, Gill, M, Gordon, S D, Gordon-Smith, K, Green, E K, Greenwood, T A, Gross, M, Grozeva, D, Guan, W, Gurling, H, Gustafsson, O, Hakonarson, H, Hamilton, S P, Hamshere, M L, Hansen, T F, Hartmann, A M, Hautzinger, M, Heath, A C, Henders, A K, Herms, S, Hickie, I B, Hipolito, M, Hoefels, S, Holmans, P A, Holsboer, F, Hottenga, J J, Hultman, C M, Ingason, A, Ising, M, Jamain, S, Jones, E G, Jones, L, Jones, I, Jung-Ying, T, Kahler, A, Kandaswamy, R, Keller, M C, Kelsoe, J, Kennedy, J L, Kenny, E, Kim, Y, Kirov, G K, Knowles, J A, Kohli, M A, Koller, D L, Konte, B, Korszun, A, Krasucki, R, Kuntsi, J, Phoenix, K, Landén, M, Langstrom, N, Lathrop, M, Lawrence, J, Lawson, W B, Leboyer, M, Lencz, T, Lewis, C M, Li, J, Lichtenstein, P, Lieberman, J A, Lin, D, Liu, C, Lohoff, F W, Loo, S K, Lucae, S, MacIntyre, D J, Madden, P A F, Magnusson, P, Mahon, P B, Maier, W, Malhotra, A K, Mattheisen, M, Matthews, K, Mattingsdal, M, McCarroll, S, McGhee, K A, McGough, J J, McGrath, P J, McGuffin, P, McInnis, M G, McIntosh, A, McKinney, R, McClean, A W, McMahon, F J, McQuillin, A, Medeiros, H, Medland, S E, Meier, S, Melle, I, Meng, F, Middeldorp, C M, Middleton, L, Vihra, M, Mitchell, P B, Montgomery, G W, Moran, J, Morken, G, Morris, D W, Moskvina, V, Mowry, B J, Muglia, P, Mühleisen, T W, Muir, W J, Müller-Myhsok, B, Myers, R M, Nelson, S F, Nievergelt, C M, Nikolovq, I, Nimgaonkar, V L, Nolen, W A, Nöthen, M M, Nwulia, E A, Nyholt, DR, O'Donovan, M C, O'Dushlaine, C, Oades, R D, Olincy, A, Olsen, L, Ophoff, R A, Osby, U, Óskarsson, H, Owen, M J, Palotie, A, Pato, M T, Pato, C N, Penninx, B W J H, Pergadia, M L, Petursson, H, Pickard, B S, Pimm, J, Piven, J, Porgeirsson, P, Posthuma, D, Potash, J B, Propping, J, Puri, V, Quested, D, Quinn, E M, Rasmussen, H B, Raychaudhuri, S, Rehnström, K, Reif, A, Rice, J, Rossin, L, Rothenberger, A, Rouleau, G, Ruderfer, D, Rujescu, D, Sanders, A R, Schalling, M, Schatzberg, A F, Scheftner, W A, Schellenberg, G D, Schofield, P R, Schork, N J, Schumacher, J, Schwarz, M M, Scolnick, E, Scott, L J, Shi, J, Shillling, P D, Shyn, S I, Sigurdsson, E, Silverman, J M, Sklar, P, Slager, S L, Smalley, S L, Smit, J H, Smith, E N, Sonuga-Barke, E, St Clair, D, State, M, Stefansson, K, Stefansson, H, Steffans, M, Steinberg, S, Steinhausen, H C, Strauss, J, Strohmaier, J, Stroup, T S, Sutcliffe, J, Szatmari, P, Szelinger, S, Thirumalai, S, Thompson, R C, Tozzi, F, Treutlein, J, Uhr, M, van den Oord, E J, Grootheest, G, Vieland, V, Vincent, J B, Visscher, P M, Watson, S J, Weissman, M M, Werge, T, Wienker, T F, Willemsen, G, Williamson, R, Witt, S H, Wray, N R, Wright, A, Xu, W, Young, A H, Zammit, S, Zandi, P P, Zhang, P, Zitman, F G, Zöllner, S & Kendler, K S 2013, ' Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis ', Lancet, vol. 381, no. 9875, pp. 1371-1379 . https://doi.org/10.1016/S0140-6736(12)62129-1, Lancet, 381(9875), 1371-1379. Elsevier Science, The Lancet (London), 381, 9875, pp. 1371-9
- Accession number :
- edsair.doi.dedup.....aa8672dc6121542d3ab63c886b89c41b
- Full Text :
- https://doi.org/10.1016/S0140-6736(12)62129-1