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Macrophages in Healing Wounds: Paradoxes and Paradigms
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 22, Iss 950, p 950 (2021)
- Publication Year :
- 2022
- Publisher :
- University of Illinois at Chicago, 2022.
-
Abstract
- Macrophages are prominent cells in normally healing adult skin wounds, yet their exact functions and functional significance to healing outcomes remain enigmatic. Many functional attributes are ascribed to wound macrophages, including host defense and support of the proliferation of new tissue to replace that lost by injury. Indeed, the depletion of macrophages is unmistakably detrimental to normal skin healing in adult mammals. Yet in certain systems, dermal wounds seem to heal well with limited or even no functional macrophages, creating an apparent paradox regarding the function of this cell in wounds. Recent advances in our understanding of wound macrophage phenotypes, along with new information about cellular plasticity in wounds, may provide some explanation for the apparently contradictory findings and suggest new paradigms regarding macrophage function in wounds. Continued study of this remarkable cell is needed to develop effective therapeutic options to improve healing outcomes.
- Subjects :
- 0301 basic medicine
Adult
Skin wound
Cell Plasticity
Inflammation
Review
Bioinformatics
scar
Catalysis
lcsh:Chemistry
Inorganic Chemistry
03 medical and health sciences
0302 clinical medicine
medicine
Genetics
Macrophage
Animals
Humans
Physical and Theoretical Chemistry
lcsh:QH301-705.5
Molecular Biology
Healing wounds
Spectroscopy
Skin
Mammals
Wound Healing
integumentary system
business.industry
Regeneration (biology)
Macrophages
Organic Chemistry
General Medicine
Computer Science Applications
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
Cellular plasticity
030220 oncology & carcinogenesis
regeneration
FOS: Biological sciences
medicine.symptom
Wound healing
business
Normal skin
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 22, Iss 950, p 950 (2021)
- Accession number :
- edsair.doi.dedup.....aa8a939f77035794a9c5479469aecb6f
- Full Text :
- https://doi.org/10.25417/uic.19608696.v1