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Shedding Light on the Pathophysiology of Preeclampsia-Syndrome in the Era of Cardio-Obstetrics: Role of Inflammation and Endothelial Dysfunction
- Source :
- Current Hypertension Reviews. 18:17-33
- Publication Year :
- 2022
- Publisher :
- Bentham Science Publishers Ltd., 2022.
-
Abstract
- Background: Preeclampsia (PE) is a pregnancy complication with serious maternal and neonatal consequences worldwide. Our understanding of PE pathophysiology has significantly evolved over the last decades by recognizing that endothelial dysfunction and systemic inflammation, with an associated angiogenic imbalance, are key pieces of this incomplete puzzle. In the present era, where no single treatment to cure or treat this obstetric condition has been developed so far, PE prevention and early prediction are the most useful clinical approach to reduce the PE burden. Introduction: Although most PE episodes occur in healthy nulliparous women, the identification of specific clinical conditions that increase the risk of PE dramatically provides a critical opportunity to improve outcomes by acting on potentially reversible factors, and also contributes to better understand this pathophysiologic enigma. Methods: Pertinent studies were searched in PubMed/Medline and Google Scholar (updated August 2020) using common keywords applied in the field of preeclampsia, inflammation and endothelial dysfunction. Given the design of this work as a narrative review, no formal criteria for study selection or appraisal were utilized. Conclusion: In this review, we highlight major clinical contributors of PE and shed light on their potential link with endothelial dysfunction and inflammation.
- Subjects :
- medicine.medical_specialty
Inflammation
030204 cardiovascular system & hematology
Systemic inflammation
Preeclampsia
03 medical and health sciences
0302 clinical medicine
Pre-Eclampsia
Pregnancy
Early prediction
Internal Medicine
medicine
Humans
030212 general & internal medicine
Endothelial dysfunction
Intensive care medicine
business.industry
Infant, Newborn
medicine.disease
Pathophysiology
Obstetrics
Female
medicine.symptom
Complication
business
Subjects
Details
- ISSN :
- 15734021
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Current Hypertension Reviews
- Accession number :
- edsair.doi.dedup.....aaa6ea92016cc91cb01d8c19896ea126