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Nonalcoholic Fatty Liver Disease in Women and Girls With Polycystic Ovary Syndrome
- Source :
- The Journal of Clinical Endocrinology & Metabolism. 107:258-272
- Publication Year :
- 2021
- Publisher :
- The Endocrine Society, 2021.
-
Abstract
- ContextNonalcoholic fatty liver disease (NAFLD) describes a spectrum of liver damage due to excessive hepatic lipid accumulation. Recent research has demonstrated a high prevalence of NAFLD in women with polycystic ovary syndrome (PCOS).ResultsStrong associations independent of body mass index (BMI) have been found between high androgen levels characteristic of PCOS, as well as insulin resistance, and the presence of NAFLD in these women, suggesting that these factors contribute to liver injury more significantly than obesity. Current studies indicate the occurrence of NAFLD in normal weight women with PCOS in addition to the commonly researched women who are overweight and obese. While the majority of studies address NAFLD in adult, premenopausal women (ages 25-40 years), the occurrence of NAFLD in young and adolescent women has gone largely unaddressed. Research in this field lacks diversity; a majority of studies either focus on populations of White women or are missing demographic information entirely.ConclusionsFuture studies should include larger, more racially and ethnically inclusive populations and particular attention should be paid to how excess androgens and insulin resistance contribute to the increased risk of NAFLD seen in women with PCOS of varying weights, ages, and ethnicities.Objective and MethodsHere, we review NAFLD in women with PCOS with subsections focused on the impact of hyperandrogenism, BMI, insulin resistance and age. Most notably, we present the most up-to-date racially and ethnically diverse worldwide prevalence of NAFLD in women with PCOS compared with women without PCOS (51.56% vs 29.64%, P < .001, respectively).
- Subjects :
- medicine.medical_specialty
medicine.drug_class
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
Physiology
Overweight
Biochemistry
Global Burden of Disease
Endocrinology
Insulin resistance
Non-alcoholic Fatty Liver Disease
Risk Factors
Internal medicine
Nonalcoholic fatty liver disease
Prevalence
medicine
Humans
business.industry
Biochemistry (medical)
Hyperandrogenism
nutritional and metabolic diseases
medicine.disease
Androgen
Polycystic ovary
Obesity
Female
Metabolic syndrome
medicine.symptom
business
Polycystic Ovary Syndrome
Subjects
Details
- ISSN :
- 19457197 and 0021972X
- Volume :
- 107
- Database :
- OpenAIRE
- Journal :
- The Journal of Clinical Endocrinology & Metabolism
- Accession number :
- edsair.doi.dedup.....aadccc144bb7ef7a6925728f25e053ab