Back to Search
Start Over
Immunological function of Langerhans cells in HIV infection
Immunological function of Langerhans cells in HIV infection
- Source :
- Journal of Dermatological Science. 87:159-167
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Background Langerhans cells (LCs) are one of the initial target cells for HIV following sexual exposure and they are productively infected by HIV. HIV-infected LCs migrate to the draining lymph nodes (dLNs) and transmit the virus to CD4+ T cells, leading to the dissemination of HIV. In contrast with the role of LCs in initial HIV acquisition, little is known about the modulation of immune responses by HIV-infected LCs. Objective We aimed to elucidate the induction of HIV-specific CD8+ T cells and regulatory T cells (Tregs), both of which play important roles in regulating the progression of HIV infection. Methods We examined the inducibility of HLA-A*0201 restricted HIV-specific CD8+ T cells and Tregs by HIV-primed LCs or HIV-primed dendritic cells (DCs) as a control. Results The number of HIV-specific CD8+ T cells induced by HIV-primed monocyte-derived LCs (mLCs) was significantly higher than that by HIV-primed monocyte-derived DCs (mDCs). Additionally, HIV-specific CD8+ T cells induced by HIV-primed mLCs produced more IFN-γ than HIV-nonspecific CD8+ T cells. HIV-primed human epidermal LCs also induced IFN-γ-producing HIV-specific CD8+ T cells. As for the induction of Tregs, HIV-primed mLCs and human epidermal LCs significantly impaired the induction of FoxP3hiCD45RA− effector Tregs than HIV-unprimed mLCs and human epidermal LCs. Conclusions HIV-primed LCs trigger beneficial immune responses against HIV infection through the increased induction of HIV-specific CD8+ T cells and the decreased induction of effector Tregs in the initial phase of HIV infection, thereby contributing to the prolonged onset of AIDS.
- Subjects :
- 0301 basic medicine
Cell Count
chemical and pharmacologic phenomena
Dermatology
CD8-Positive T-Lymphocytes
Biology
Lymphocyte Activation
T-Lymphocytes, Regulatory
Biochemistry
Peripheral blood mononuclear cell
Virus
Tissue Culture Techniques
03 medical and health sciences
Immune system
HLA-A2 Antigen
Humans
Cytotoxic T cell
Antigen-presenting cell
Molecular Biology
Cells, Cultured
Acquired Immunodeficiency Syndrome
Toll-like receptor
integumentary system
Effector
virus diseases
hemic and immune systems
030104 developmental biology
Epidermal Cells
Langerhans Cells
Immunology
Disease Progression
HIV-1
Epidermis
CD8
Subjects
Details
- ISSN :
- 09231811
- Volume :
- 87
- Database :
- OpenAIRE
- Journal :
- Journal of Dermatological Science
- Accession number :
- edsair.doi.dedup.....aae245a6df4d7020e57a543a623012e9
- Full Text :
- https://doi.org/10.1016/j.jdermsci.2017.03.015