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Impaired meningeal lymphatic vessel development worsens stroke outcome
- Source :
- Journal of Cerebral Blood Flow & Metabolism
- Publication Year :
- 2019
-
Abstract
- The discovery of meningeal lymphatic vessels (LVs) has sparked interest in identifying their role in diseases of the central nervous system. Similar to peripheral LVs, meningeal LVs depend on vascular endothelial growth factor receptor-3 (VEGFR3) signaling for development. Here we characterize the effect of stroke on meningeal LVs, and the impact of meningeal lymphatic hypoplasia on post-stroke outcomes. We show that photothrombosis (PT), but not transient middle cerebral artery occlusion (tMCAo), induces meningeal lymphangiogenesis in young male C57Bl/J6 mice. We also show that Vegfr3wt/mut mice develop significantly fewer meningeal LVs than Vegfr3wt/wt mice. Again, meningeal lymphangiogenesis occurs in the alymphatic zone lateral to the sagittal sinus only after PT-induced stroke in Vegfr3wt/wt mice. Interestingly, Vegfr3wt/mut mice develop larger stroke volumes than Vegfr3wt/wt mice after tMCAo, but not after PT. Our results reveal differences between PT and tMCAo models of stroke and underscore the need to consider method of stroke induction when investigating the role of meningeal lymphatics. Taken together, our data indicate that ischemic injury can induce the growth of meningeal LVs and that the absence of these LVs can impact post-stroke outcomes.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Meningeal lymphatic vessels
Central nervous system
Mice, Transgenic
03 medical and health sciences
chemistry.chemical_compound
Mice
0302 clinical medicine
Lymphatic vessel
Medicine
Animals
Stroke
meningeal lymphatics
030304 developmental biology
0303 health sciences
business.industry
Original Articles
medicine.disease
Vascular Endothelial Growth Factor Receptor-3
Lymphangiogenesis
Vascular endothelial growth factor
lymphangiogenesis
Disease Models, Animal
Lymphatic system
medicine.anatomical_structure
Neurology
chemistry
Glymphatic system
Neurology (clinical)
Cardiology and Cardiovascular Medicine
business
Glymphatic System
VEGFR3
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15597016
- Volume :
- 40
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
- Accession number :
- edsair.doi.dedup.....aaf6b7dc631d5279fc1989163b8f6772