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Chemical and Biological Investigation of Ochrosia elliptica Labill. Cultivated in Egypt
- Source :
- Records of Natural Products, Vol 11, Iss 6, Pp 552-557 (2017)
- Publication Year :
- 2017
- Publisher :
- ACG Publications, 2017.
-
Abstract
- The phytochemical investigation of Ochrosia eliptica leaves resulted in isolation and identification of eight compounds; lupeol, lupeol acetate, uvaol, ursolic acid, β-sitosterol glucoside, rutin, 8-methoxy and 9-methoxy ellipticine . The ethanolic extract and fractions were studied for their cytotoxic, antioxidant and anti-inflammatory activities. The cytotoxic activity was performed on human mammary adenocarcinoma (MCF7), its multidrug-resistant counterpart (VCREMS), estrogen receptor negative human metastatic breast adenocarcinoma cells (MDA-MB-231) and the non-cancerous, immortalized by telomerase, human breast epithelial cell line (hTERT-HME1). Additionally, the inhibitory potential on Cdc25s proteins was determined. The results showed that the dichloromethane (DCM) fraction and the major alkaloid; 9-methoxyellipticine exhibited high inhibitory activity against all tested cell lines particularly MCF7 and VCREMS cell lines, whereas t he DCM fraction showed a significant inhibitory action on Cdc25 A isoform. In contrast, the n-butanol fraction and 9-methoxyellipticine displayed the highest antioxidant potential. The DCM fraction showed significant anti-inflammatory activity compared to indomethacin. This work comprises the first comprehensive work to be conducted on O. elliptica leaves showing its potential in multiple biological activities .
- Subjects :
- Pharmacology
Ochrosia elliptica
010405 organic chemistry
Organic Chemistry
Plant Science
Biology
biology.organism_classification
01 natural sciences
Cdc25s
0104 chemical sciences
lcsh:QK1-989
lcsh:Chemistry
lcsh:QD241-441
010404 medicinal & biomolecular chemistry
lcsh:QD1-999
lcsh:Organic chemistry
lcsh:Botany
Drug Discovery
Botany
cytotoxicity
methoxy ellipticine
anti-inflammatory
Subjects
Details
- Language :
- English
- ISSN :
- 13076167
- Volume :
- 11
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Records of Natural Products
- Accession number :
- edsair.doi.dedup.....aafa5cf886d2a1ef388faf4aec7c5f96