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Synthesis of Poly(N-vinylpyrrolidone)-Based Polymer Bottlebrushes by ATRPA and RAFT Polymerization: Toward Drug Delivery Application
- Source :
- Polymers, Vol 11, Iss 6, p 1079 (2019), Polymers, Volume 11, Issue 6
- Publication Year :
- 2019
- Publisher :
- MDPI AG, 2019.
-
Abstract
- Atom transfer radical polyaddition (ATRPA) was utilized herein to synthesize a specific functional polyester. We conducted ATRPA of 4-vinylbenzyl 2-bromo-2-phenylacetate (VBBPA) inimer and successfully obtained a linear type poly(VBBPA) (PVBBPA) polyester with benzylic bromides along the backbone. To obtain a novel amphiphilic polymer bottlebrush, however, the lateral ATRP chain extension of PVBBPA with N-vinyl pyrrolidone (NVP) met the problem of quantitative dimerization. By replacing the bromides to xanthate moieties efficiently, we thus observed a pseudo linear first order reversible addition&ndash<br />fragmentation chain transfer (RAFT) polymerization to obtain novel poly(4-vinylbenzyl-2-phenylacetate)-g-poly(NVP) (PVBPA-g-PNVP) amphiphilic polymer bottlebrushes. The critical micelle concentration (CMC) and particle size of the amphiphilic polymer bottlebrushes were characterized by fluorescence spectroscopy, dynamic light scattering (DLS), and scanning electron microscopy (SEM) (CMCs &lt<br />0.5 mg/mL<br />particle sizes = ca. 100 nm). Toward drug delivery application, we examined release profiles using a model drug of Nile red at different pH environments (3, 5, and 7). Eventually, low cytotoxicity and well cell uptake of the Madin-Darby Canine Kidney Epithelial (MDCK) for the polymer bottlebrush micelles were demonstrated.
- Subjects :
- chemistry.chemical_classification
Polymers and Plastics
reversible addition–fragmentation chain transfer (RAFT) polymerization
Chain transfer
poly(N-vinylpyrrolidone)
General Chemistry
Raft
Polymer
atom transfer radical polyaddition (ATRPA)
Micelle
Article
lcsh:QD241-441
chemistry
Dynamic light scattering
Polymerization
lcsh:Organic chemistry
Critical micelle concentration
Polymer chemistry
Reversible addition−fragmentation chain-transfer polymerization
functional polyesters
amphiphilic polymer bottlebrush
Subjects
Details
- Language :
- English
- ISSN :
- 20734360
- Volume :
- 11
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Polymers
- Accession number :
- edsair.doi.dedup.....ab1df7a7716b1398067bad13aab98e1a