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Effects of nasal lavage with and without mupirocin after endoscopic endonasal skull base surgery: a randomised, controlled study
- Source :
- The Journal of Laryngology & Otology. 133:1059-1063
- Publication Year :
- 2019
- Publisher :
- Cambridge University Press (CUP), 2019.
-
Abstract
- BackgroundNasal lavage with mupirocin has the potential to reduce sinonasal morbidity in endoscopic endonasal approaches for skull base surgery.ObjectiveTo evaluate the effects of nasal lavage with and without mupirocin after endoscopic endonasal skull base surgery.MethodsA pilot randomised, controlled trial was conducted on 20 adult patients who had undergone endoscopic endonasal approaches for skull base lesions. These patients were randomly assigned to cohorts using nasal lavages with mupirocin or without mupirocin. Patients were assessed in the out-patient clinic, one week and one month after surgery, using the 22-item Sino-Nasal Outcome Test questionnaire and nasal endoscopy.ResultsPatients in the mupirocin nasal lavage group had lower nasal endoscopy scores post-operatively, and a statistically significant larger difference in nasal endoscopy scores at one month compared to one week. The mupirocin nasal lavage group also showed better Sino-Nasal Outcome Test scores at one month compared to the group without mupirocin.ConclusionNasal lavage with mupirocin seems to yield better outcomes regarding patients’ symptoms and endoscopic findings.
- Subjects :
- Adult
Male
medicine.medical_specialty
Nasal Surgical Procedures
Pilot Projects
Mupirocin
Skull Base Neoplasms
law.invention
Young Adult
chemistry.chemical_compound
Postoperative Complications
Randomized controlled trial
law
otorhinolaryngologic diseases
medicine
Humans
Aged
Skull Base
Nasal endoscopy
Adult patients
business.industry
Endoscopy
General Medicine
Antibiotic Prophylaxis
Middle Aged
Surgery
Skull
Endoscopic surgical procedure
Treatment Outcome
medicine.anatomical_structure
Otorhinolaryngology
chemistry
Skull base surgery
Nasal Lavage
Female
business
Subjects
Details
- ISSN :
- 17485460 and 00222151
- Volume :
- 133
- Database :
- OpenAIRE
- Journal :
- The Journal of Laryngology & Otology
- Accession number :
- edsair.doi.dedup.....ab20f730bff92a834148b3af42cc6488