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Masseter muscle and gingival tissue inflammatory response following treatment with high‐fructose corn syrup in rats: Anti‐inflammatory and antioxidant effects of kefir
- Source :
- Journal of Food Biochemistry. 46
- Publication Year :
- 2021
- Publisher :
- Hindawi Limited, 2021.
-
Abstract
- The aim of the study was to evaluate whether high-fructose corn syrup (HFCS) intake (20% beverages) impacts antioxidative structures and inflammation in the gingival tissue and masseter muscle of rats. Kefir was tested for its potential utility on changes induced by HFCS. Animals were randomly divided into four groups as control, kefir, HFCS, and HFCS plus kefir. HFCS was given as 20% solutions in drinking water while kefir supplementations were given by gastric gavage for 8 weeks. It has been clearly determined that the HFCS diet increased expressions of interleukin (IL)-6, IL-1β, and tumor necrosis factor-α proinflammatory structures via lymphocyte infiltration by suppressing antioxidant enzymes such as catalase, superoxide dismutase, and glutathione peroxidase in both tissues. Kefir improved these undesirable changes in rats fed with HFCS. The results of this current study, the first investigation to examine the effects of kefir on masseter muscle and gingival tissue, may provide new access to the restorative effects of kefir consumption on oral health disorders caused by high fructose in the diet. PRACTICAL APPLICATIONS: In this study, at an early age, the effects of kefir on improving inflammation via antioxidation in the masseter muscle and gingival tissue were investigated for the first time. We showed that kefir feeding ameliorates lymphocyte infiltration on the high-fructose corn syrup (HFCS)-induced masseter muscle and gingival tissue inflammation in rats. The mRNA expressions of inflammatory parameters measured in the study were supported by protein measurements via ELISA or immunohistochemistry. In the present study, kefir may play an important role in the antioxidation and inflammation process on the masseter muscle and gingival tissue against HFCS.
- Subjects :
- medicine.medical_specialty
food.ingredient
030309 nutrition & dietetics
medicine.drug_class
Anti-Inflammatory Agents
Biophysics
Inflammation
Fructose
Zea mays
Antioxidants
Anti-inflammatory
Proinflammatory cytokine
Masseter muscle
Superoxide dismutase
03 medical and health sciences
Kefir
0404 agricultural biotechnology
food
Internal medicine
medicine
Animals
Pharmacology
chemistry.chemical_classification
0303 health sciences
biology
Masseter Muscle
High-fructose corn syrup
business.industry
Glutathione peroxidase
04 agricultural and veterinary sciences
Cell Biology
040401 food science
Rats
Corn syrup
Endocrinology
chemistry
biology.protein
medicine.symptom
business
High Fructose Corn Syrup
Food Science
Subjects
Details
- ISSN :
- 17454514 and 01458884
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- Journal of Food Biochemistry
- Accession number :
- edsair.doi.dedup.....ab2490d0031111786d5b3ae480a4f361