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Association of transcription factor 7-like 2 (rs7903146) gene polymorphism with diabetic retinopathy
- Source :
- Ophthalmic Genetics. 41:420-426
- Publication Year :
- 2020
- Publisher :
- Informa UK Limited, 2020.
-
Abstract
- Diabetic retinopathy (DR) is one of the most common diabetic complications. Genetic factors play an important role in the development and progression of DR. So, the present study aimed to investigate the association ofThis work is a case-control study in which 550 diabetic patients were enrolled. Among them, 280 diabetics with DR (120 T1DM and 160 with T2DM) and 270 diabetic patients without DR (120 T1DM and 150 with T2DM). Besides, 120 healthy subjects as a control group. Genotyping ofC allele and CC genotype ofThe present study revealed the association of
- Subjects :
- Adult
Male
0301 basic medicine
Adolescent
Genotype
030105 genetics & heredity
Bioinformatics
Polymorphism, Single Nucleotide
Transcription Factor 7-Like 2
Young Adult
03 medical and health sciences
0302 clinical medicine
Risk Factors
Humans
Medicine
Genetic Predisposition to Disease
Genetics (clinical)
Aged
Diabetic Retinopathy
business.industry
Diabetic retinopathy
Middle Aged
medicine.disease
Ophthalmology
Diabetes Mellitus, Type 2
Case-Control Studies
Pediatrics, Perinatology and Child Health
030221 ophthalmology & optometry
Egypt
Female
Gene polymorphism
business
Transcription Factor 7-Like 2 Protein
TCF7L2
Subjects
Details
- ISSN :
- 17445094 and 13816810
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Ophthalmic Genetics
- Accession number :
- edsair.doi.dedup.....ab2d680f82db43ee381e497b702cd22f
- Full Text :
- https://doi.org/10.1080/13816810.2020.1780620