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The Effect of Protandim® Supplementation on Athletic Performance and Oxidative Blood Markers in Runners
- Source :
- PLoS ONE, PLoS ONE, Vol 15, Iss 10, p e0241520 (2020), PloS one, vol 15, iss 10, PloS one, vol 11, iss 8, PLoS ONE, Vol 11, Iss 8, p e0160559 (2016)
- Publication Year :
- 2016
- Publisher :
- Public Library of Science, 2016.
-
Abstract
- The purpose of this study determined if oral supplementation of Protandim® (a nutraceutical) for 90 days improved 5-km running performance and reduced serum thiobarbituric acid-reacting substances (TBARS) at rest, an indicator of oxidative stress. Secondary objectives were to measure whole blood superoxide dismutase (SOD), glutathione (GSH), and glutathione peroxidase (GPX), at rest and 10 minutes after completion of the race before and after supplementation as well as quality of life. In a double-blind, randomized, placebo controlled trial, 38 runners [mean (SD) = 34 (7) yrs; BMI = 22 (2) kg/m2] received either 90 days of Protandim® [1 pill a day, n = 19)] or placebo (n = 19). Randomization was done in blocks of two controlling for sex and 5-km baseline performance. A 5-km race was performed at baseline and after 90 days of supplementation, with blood samples taken before and 10-min after each race. Fasting blood samples were acquired at baseline, after 30, 60, and 90 days of supplementation. TBARS, SOD, GPX, and GSH were assayed in an out-of-state accredited lab. Running performance was not altered by Protandim® or placebo [20.3 (2.1) minutes, with an -8 (33) seconds change in 5-km time regardless of group]. There was no change in TBARS, SOD, or GPX (at rest) after three months of Protandim® supplementation compared to placebo. However, in a subgroup ≥ 35 years of age, there was a 2-fold higher increase in SOD in those taking Protandim® for three months compared to those on placebo (p = 0.038). The mean post-race change in TBARS (compared to pre-race) increased by about 20% in half of the subjects, but was not altered between groups, even after three months of supplementation. Quality of life was also not different between the two conditions. In conclusion, Protandim® did not (1) alter 5-km running time, (2) lower TBARS at rest (3) raise antioxidant enzyme concentrations compared to placebo (with exception of SOD in those ≥ 35 years old) or, (4) affect quality of life compared to placebo. Trial Registration: ClinicalTrials.gov {"type":"clinical-trial","attrs":{"text":"NCT02172625","term_id":"NCT02172625"}}NCT02172625
- Subjects :
- 0301 basic medicine
Male
Physiology
Chinese Herbal
Placebo-controlled study
lcsh:Medicine
Biochemistry
Antioxidants
law.invention
Running
Lipid peroxidation
chemistry.chemical_compound
Oxidative Damage
0302 clinical medicine
Randomized controlled trial
law
Medicine and Health Sciences
Medicine
Amino Acids
lcsh:Science
Whole blood
chemistry.chemical_classification
Multidisciplinary
Organic Compounds
Glutathione peroxidase
Drugs
Hematology
Middle Aged
Lipids
Glutathione
Body Fluids
Enzymes
Chemistry
Blood
Dismutases
6.1 Pharmaceuticals
Physical Sciences
Female
Anatomy
Oxidation-Reduction
Research Article
Adult
medicine.medical_specialty
Randomization
General Science & Technology
Science
Clinical Trials and Supportive Activities
Athletic Performance
Placebo
Thiobarbituric Acid Reactive Substances
03 medical and health sciences
Double-Blind Method
Clinical Research
Internal medicine
Complementary and Integrative Health
TBARS
Humans
Sulfur Containing Amino Acids
Cysteine
Nutrition
Glutathione Peroxidase
business.industry
Superoxide Dismutase
Prevention
lcsh:R
Organic Chemistry
Chemical Compounds
Evaluation of treatments and therapeutic interventions
Correction
Biology and Life Sciences
Proteins
030229 sport sciences
Cell Biology
Surgery
Oxidative Stress
030104 developmental biology
Endocrinology
chemistry
Dietary Supplements
Quality of Life
Enzymology
lcsh:Q
Lipid Peroxidation
business
Peptides
Drugs, Chinese Herbal
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 11
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....ab3b815be3d1624b84de7f31159696da