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Oxymetazoline hydrochloride cream for facial erythema associated with rosacea
- Source :
- Expert Review of Clinical Pharmacology. 10:1049-1054
- Publication Year :
- 2017
- Publisher :
- Informa UK Limited, 2017.
-
Abstract
- Rosacea is a chronic skin condition characterized by transient and persistent erythema of the central face. The symptom of persistent erythema can be particularly frustrating for both patients and physicians as it is difficult to treat. Areas covered: Current treatment options for the treatment of rosacea include metronidazole, azelaic acid, sodium sulfacetamide-sulfur, and brimonidine. Until recently, brimonidine gel was the only option approved specifically for the treatment of facial erythema. However, oxymetazoline hydrochloride 1% cream is a newly FDA approved topical medication for adult rosacea patients. A primarily alpha-1a agonist, oxymetazoline hydrochloride (HCl) is thought to diminish erythema through vasoconstriction. Our paper seeks to evaluate evidence for topical oxymetazoline HCl with respect to its efficacy and safety for its approved indication of treating the persistent erythema associated with rosacea. Expert commentary: While assessment of available clinical trial data indicates that the medication is as effective as other available treatment for controlling rosacea-associated erythema with minimal risk of adverse effects, studies of long-term duration and direct comparison will be necessary to establish its place in treatment guidelines and clinical practice. As further evidence becomes available, the real-world clinical potential of topical oxymetazoline cream will become clearer.
- Subjects :
- medicine.medical_specialty
Erythema
Oxymetazoline
Skin Cream
Administration, Cutaneous
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Humans
Medicine
Pharmacology (medical)
Oxymetazoline Hydrochloride
General Pharmacology, Toxicology and Pharmaceutics
skin and connective tissue diseases
integumentary system
business.industry
Brimonidine
General Medicine
medicine.disease
Dermatology
Topical medication
Metronidazole
Vasoconstriction
Rosacea
030220 oncology & carcinogenesis
Anesthesia
Dermatologic Agents
medicine.symptom
business
Adrenergic alpha-Agonists
medicine.drug
Subjects
Details
- ISSN :
- 17512441 and 17512433
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Expert Review of Clinical Pharmacology
- Accession number :
- edsair.doi.dedup.....ab3bf06d91cc81dad732d0f3f4e792b8