Back to Search
Start Over
Association between ischemic stroke and carbon monoxide poisoning: A population-based retrospective cohort analysis
- Source :
- European Journal of Internal Medicine. 29:65-70
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- The long-term consequence of cardiovascular health has not been evaluated for patients with carbon monoxide (CO) poisoning. This study evaluated the risk of ischemic stroke using population-based data.We identified 8705 inpatients with CO intoxication diagnosed from 2000 to 2011 from the Taiwan National Health Insurance Research Database. The control cohort consisted of 34,820 persons randomly identified from patients without exposure frequency matched by age, sex, and the year of hospitalization. Incidence and hazard ratio (HR) of ischemic stroke were evaluated by sociodemographic factors and comorbidities by the end of 2011.The incidence of ischemic stroke revealed a significant increase in the CO-poisoning cohort over the follow-up period (p0.001). The overall incidence of ischemic stroke was near 2.5-fold greater in the CO-poisoned cohort than in controls (5.49 versus 2.02 per 1000 person-years), with an adjusted HR of 2.60 (95% confidence interval (CI)=2.15-3.15). The adjusted HR for those without comorbidities was slightly higher (2.76, 95% CI=2.13-3.58). The age-specific CO-poisoning to non-CO-poisoning relative risk was greatest in the youngest group (20-34years) (adjusted HR=6.45; 95% CI=3.30-12.6).CO poisoning is associated with a long-term risk of increased incident ischemic stroke. Further study on the mechanism of ischemic stroke for CO poisoning affects is needed.
- Subjects :
- Adult
Male
medicine.medical_specialty
Databases, Factual
Population
Taiwan
Poison control
Comorbidity
030204 cardiovascular system & hematology
Carbon Monoxide Poisoning
Young Adult
03 medical and health sciences
Age Distribution
0302 clinical medicine
Risk Factors
Internal medicine
Internal Medicine
medicine
Humans
Sex Distribution
education
Stroke
Aged
Proportional Hazards Models
Retrospective Studies
education.field_of_study
business.industry
Incidence
Incidence (epidemiology)
Hazard ratio
030208 emergency & critical care medicine
Retrospective cohort study
Middle Aged
medicine.disease
Cohort
Physical therapy
Female
business
Cohort study
Subjects
Details
- ISSN :
- 09536205
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- European Journal of Internal Medicine
- Accession number :
- edsair.doi.dedup.....ab4662184cb95cb24148161e0dfbf5c9