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microRNA inhibitors: Natural and artificial sequestration of microRNA
- Source :
- Cancer Letters. 407:139-147
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- MicroRNA (miRNAs) is post-transcriptional regulator of mRNA. However, the prevalence and activity of miRNA are regulated by other regulators. miRNA inhibitors are natural or artificial RNA transcripts that sequestrate miRNAs and decrease or even eliminate miRNA activity. Competing endogenous RNAs (ceRNAs) are natural and intracellular miRNA inhibitors that compete to bind to shared miRNA recognition elements (MREs) to decrease microRNA availability and relieve the repression of target RNAs. In recent years, studies have revealed that ceRNA crosstalk is involved in many pathophysiological processes and adds a new dimension to miRNA regulation. Artificial miRNA inhibitors are RNA transcripts that are synthesized via chemical and genetic methods. Artificial miRNA inhibitors can be used in miRNA loss-of-function research and gene therapies for certain diseases. In this review, we summarize the recent advances in the two different types of miRNA inhibitors.
- Subjects :
- 0301 basic medicine
Genetics
Cancer Research
Messenger RNA
Competing endogenous RNA
Oligonucleotides
Regulator
RNA
Genetic Therapy
Computational biology
Biology
Gene Expression Regulation, Neoplastic
MicroRNAs
03 medical and health sciences
030104 developmental biology
Oncology
Circular RNA
Neoplasms
microRNA
Humans
Gene silencing
Gene Regulatory Networks
Gene
Pseudogenes
Subjects
Details
- ISSN :
- 03043835
- Volume :
- 407
- Database :
- OpenAIRE
- Journal :
- Cancer Letters
- Accession number :
- edsair.doi.dedup.....ab4b58eb7877db0544fb0e7d131b719b