Cryo-EM structures of prefusion SIV envelope trimer

Authors :: Jason Gorman
Chunyan Wang
Rosemarie D. Mason
Alexandra F. Nazzari
Hugh C. Welles
Tongqing Zhou
Julian W. Bess
Tatsiana Bylund
Myungjin Lee
Yaroslav Tsybovsky
Raffaello Verardi
Shuishu Wang
Yongping Yang
Baoshan Zhang
Reda Rawi
Brandon F. Keele
Jeffrey D. Lifson
Jun Liu
Mario Roederer
Peter D. Kwong
Source :: Nature structuralmolecular biology. 29(11)
Publication Year :: 2021
Abstract: Simian immunodeficiency viruses (SIVs) are lentiviruses that naturally infect non-human primates of African origin and seeded cross-species transmissions of HIV-1 and HIV-2. Here we report prefusion stabilization and cryo-EM structures of soluble envelope (Env) trimers from rhesus macaque SIV (SIV