Back to Search
Start Over
Genome-wide copy number variant analysis reveals variants associated with 10 diverse production traits in Holstein cattle
- Source :
- BMC Genomics, Vol 19, Iss 1, Pp 1-9 (2018), BMC Genomics
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- Background Copy number variation (CNV) is an important type of genetic variation contributing to phenotypic differences among mammals and may serve as an alternative molecular marker to single nucleotide polymorphism (SNP) for genome-wide association study (GWAS). Recently, GWAS analysis using CNV has been applied in livestock, although few studies have focused on Holstein cattle. Results We describe 191 CNV detected using intensity data from over 700,000 SNP genotypes generated with the BovineHD Genotyping BeadChip (Illumina, San Diego, CA) in 528 Holstein cows. The CNV were used for GWAS analysis of 10 important production traits of 473 cattle related to feed intake, milk quality, and female fertility, as well as 2 composite traits of net merit and productive life. In total, we detected 57 CNV associated (P
- Subjects :
- 0301 basic medicine
Genome-wide association study
Candidate gene
DNA Copy Number Variations
Genotyping Techniques
Feed intake
lcsh:QH426-470
Feed efficiency
lcsh:Biotechnology
Quantitative Trait Loci
Single-nucleotide polymorphism
Biology
Polymorphism, Single Nucleotide
03 medical and health sciences
chemistry.chemical_compound
lcsh:TP248.13-248.65
Molecular marker
Genetic variation
Dairy cow
Genetics
Animals
Copy-number variation
Gene
0402 animal and dairy science
Genomics
04 agricultural and veterinary sciences
040201 dairy & animal science
Copy number variation (CNV)
lcsh:Genetics
Fertility
Milk
Phenotype
030104 developmental biology
chemistry
Cattle
Female
Residual feed intake
Research Article
Biotechnology
Subjects
Details
- ISSN :
- 14712164
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- BMC Genomics
- Accession number :
- edsair.doi.dedup.....ab7308dc009246eceedc971c4a476b45