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Perinatal Licensing of Thermogenesis by IL-33 and ST2
- Source :
- Cell, vol 166, iss 4
- Publication Year :
- 2016
- Publisher :
- eScholarship, University of California, 2016.
-
Abstract
- For placental mammals, the transition from the in utero maternal environment to postnatal life requires the activation of thermogenesis to maintain their core temperature. This is primarily accomplished by induction of uncoupling protein 1 (UCP1) in brown and beige adipocytes, the principal sites for uncoupled respiration. Despite its importance, how placental mammals license their thermogenic adipocytes to participate in postnatal uncoupled respiration is not known. Here, we provide evidence that the "alarmin" IL-33, a nuclear cytokine that activates type 2 immune responses, licenses brown and beige adipocytes for uncoupled respiration. We find that, in absence of IL-33 or ST2, beige and brown adipocytes develop normally but fail to express an appropriately spliced form of Ucp1 mRNA, resulting in absence of UCP1 protein and impairment in uncoupled respiration and thermoregulation. Together, these data suggest that IL-33 and ST2 function as a developmental switch to license thermogenesis during the perinatal period. PAPERCLIP.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Cellular respiration
medicine.medical_treatment
Cell Respiration
Interleukin-1 Receptor-Like 1 Protein
Biology
Inbred C57BL
Medical and Health Sciences
Article
Ion Channels
General Biochemistry, Genetics and Molecular Biology
Mitochondrial Proteins
03 medical and health sciences
Mice
Adipose Tissue, Brown
Internal medicine
Respiration
medicine
Adipocytes
Humans
Animals
Lymphocytes
Pediatric
Parturition
Thermogenesis
Thermoregulation
Biological Sciences
Newborn
Interleukin-33
Thermogenin
Interleukin 33
Cold Temperature
030104 developmental biology
Cytokine
Endocrinology
Female
Developmental Biology
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Cell, vol 166, iss 4
- Accession number :
- edsair.doi.dedup.....ab8cdb00c28356c48d143f4234e56ab1